cis- and trans-Dihalotetrakis(dimethyl sulfoxide)ruthenium(II) complexes (RuX/sub 2/(DMSO)/sub 4/; X = Cl, Br): Synthesis, structure, and antitumor activity
The chemistry of halogen-dimethyl sulfoxide-ruthenium(II) complexes with the general formula RuX/sub 2/(DMSO)/sub 4/ (X = Cl, Br) is reported. In particular the synthesis and x-ray structure of trans-RuCl/sub 2/(DMSO)/sub 4/ are described and compared with those of the already known cis-RuCl/sub 2/(DMSO)/sub 4/ and trans-RuBr/sub 2/(DMSO)/sub 4/. The structure op a new crystal form of cis-RuCl/sub 2/(DMSO)/sub 4/ is also reported. While the cis isomers are thermodynamically more stable and form from the trans species a photochemically driven cis to trans isomerization reaction is observed in dimethyl sulfoxide solution. Kinetic parameters for the thermal trans to cis isomerization reactions for trans-RuCl/sub 2/(DMSO)/sub 4/ and trans-RuBr/sub 2/(DMSO)/sub 4/ are reported. In chloroform solution the complexes, and in particular the trans isomers, tend to release a dimethyl sulfoxide molecule to give pentacoordinated Ru(II) complexes. However, in aqueous solution, while the cis complexes immediately release one DMSO, the trans ones release two. In both cases, this step is followed by the slow dissociation of a halide ion. For the chloro derivatives the dissociation is completely inhibited at physiological chloride concentrations. Preliminary results from pharmacological tests show that trans-RuCl/sub 2/(CMSO)/sub 4/ is more active than the cis isomer against Lewis lung carcinoma, a metastasizing murine tumor. A remarkable dependence of activity on the halogen nature (Cl > Br) is also observed. 33 refs., 4 figs., 9 tabs.
- Research Organization:
- Universita di Trieste (Italy)
- OSTI ID:
- 5722066
- Journal Information:
- Inorg. Chem.; (United States), Vol. 27:23
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
37 INORGANIC
ORGANIC
PHYSICAL AND ANALYTICAL CHEMISTRY
DMSO
SYNTHESIS
NEOPLASMS
CHEMOTHERAPY
RUTHENIUM COMPOUNDS
EXPERIMENTAL DATA
MOLECULAR STRUCTURE
DATA
DISEASES
INFORMATION
NUMERICAL DATA
ORGANIC COMPOUNDS
ORGANIC SULFUR COMPOUNDS
REFRACTORY METAL COMPOUNDS
SULFOXIDES
THERAPY
TRANSITION ELEMENT COMPOUNDS
550600* - Medicine
400201 - Chemical & Physicochemical Properties
400202 - Isotope Effects
Isotope Exchange
& Isotope Separation