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Title: Development of a new osmium-191-iridium-191m radionuclide generator. Annual report

Abstract

The major limitation of the Cheng generator design is the chemical instability of the parent trans-dioxotetrachloroosmate(VI) complex. Efforts reported here were directed towards the evaluation of alternative osmium complexes for use as the parent species. Several non-chloro osmium complexes were synthesized that proved to be promising for generator applications and /sup 191/Os-/sup 191m/Ir generators were subsequently developed using these complexes as the parent species. One of these generators (''oxalate'') was found to be particularly promising and has been optimized for potential human use (IND application pending). Although the ''oxalate'' generator provides twice the /sup 191m/Ir yield and less than one-tenth the /sup 191/Os breakthrough of earlier designs, the yield of the generator remains low (30%/mL) and decreases with time to 15 to 20%/mL. 16 refs., 16 tabs.

Authors:
;
Publication Date:
Research Org.:
Children's Hospital Medical Center, Boston, MA (USA). Dept. of Radiology
OSTI Identifier:
5720972
Report Number(s):
DOE/ER/60084-5
ON: DE86010371
DOE Contract Number:  
AC02-82ER60084
Resource Type:
Technical Report
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; 38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY; IRIDIUM 191; RADIOISOTOPE GENERATORS; OSMIUM 191; TISSUE DISTRIBUTION; OSMIUM COMPLEXES; TOXICITY; DESIGN; EXPERIMENTAL DATA; ION EXCHANGE CHROMATOGRAPHY; ISOMERIC NUCLEI; OXALATES; PH VALUE; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; CARBOXYLIC ACID SALTS; CHROMATOGRAPHY; COMPLEXES; DATA; DAYS LIVING RADIOISOTOPES; DISTRIBUTION; EVEN-ODD NUCLEI; HEAVY NUCLEI; HOURS LIVING RADIOISOTOPES; INFORMATION; IRIDIUM ISOTOPES; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; MINUTES LIVING RADIOISOTOPES; NUCLEI; NUMERICAL DATA; ODD-EVEN NUCLEI; OSMIUM ISOTOPES; RADIOISOTOPES; SECONDS LIVING RADIOISOTOPES; SEPARATION PROCESSES; STABLE ISOTOPES; TRANSITION ELEMENT COMPLEXES; 550601* - Medicine- Unsealed Radionuclides in Diagnostics; 400703 - Radiochemistry & Nuclear Chemistry- Radioisotope Production

Citation Formats

Treves, S, and Packard, A B. Development of a new osmium-191-iridium-191m radionuclide generator. Annual report. United States: N. p., 1986. Web.
Treves, S, & Packard, A B. Development of a new osmium-191-iridium-191m radionuclide generator. Annual report. United States.
Treves, S, and Packard, A B. Wed . "Development of a new osmium-191-iridium-191m radionuclide generator. Annual report". United States.
@article{osti_5720972,
title = {Development of a new osmium-191-iridium-191m radionuclide generator. Annual report},
author = {Treves, S and Packard, A B},
abstractNote = {The major limitation of the Cheng generator design is the chemical instability of the parent trans-dioxotetrachloroosmate(VI) complex. Efforts reported here were directed towards the evaluation of alternative osmium complexes for use as the parent species. Several non-chloro osmium complexes were synthesized that proved to be promising for generator applications and /sup 191/Os-/sup 191m/Ir generators were subsequently developed using these complexes as the parent species. One of these generators (''oxalate'') was found to be particularly promising and has been optimized for potential human use (IND application pending). Although the ''oxalate'' generator provides twice the /sup 191m/Ir yield and less than one-tenth the /sup 191/Os breakthrough of earlier designs, the yield of the generator remains low (30%/mL) and decreases with time to 15 to 20%/mL. 16 refs., 16 tabs.},
doi = {},
url = {https://www.osti.gov/biblio/5720972}, journal = {},
number = ,
volume = ,
place = {United States},
year = {1986},
month = {4}
}

Technical Report:
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