Persistence of cadmium-induced metabolic changes in liver and kidney
Daily intraperitoneal injection of cadmium chloride (1 milligram per kilogram) for 45 days enhanced gluconeogenesis as evidenced by significant increases in the activities of liver and kidney cortex pyruvate carboxylase, phosphopyruvate carboxylase, hexosediphosphatase, and glucose-6-phosphatase, the quartet of key, rate-limiting enzymes involved in the biotransformation of non-carbohydrate precursors into glucose. Whereas cadmium treatment decreased the level of hepatic glycogen, the concentration of blood glucose and urea was significantly elevated by this heavy metal. Discontinuation of the heavy metal treatment for 28 days, in rats previously injected with cadmium for 45 days, failed to restore the observed biochemical alterations in hepatic and renal carbohydrate metabolism to control values. Evidence indicates that cadmium augments the glucose-synthesizing capacity of liver and kidney cortex and that various metabolic changes persist even after a 4-week period of withdrawal from exposure to the heavy metal. 14 references, 2 tables.
- Research Organization:
- Univ. of Ottawa, Ontario
- OSTI ID:
- 5720291
- Journal Information:
- Science (Washington, D.C.); (United States), Vol. 183:4129
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
CADMIUM
BIOLOGICAL EFFECTS
CADMIUM CHLORIDES
INTRAPERITONEAL INJECTION
BIOSYNTHESIS
BLOOD CHEMISTRY
CARBOXYLASE
ENZYME ACTIVITY
GLUCOSE
KIDNEYS
LIVER
METABOLISM
PHOSPHATASES
RATS
STIMULATION
ALDEHYDES
ANIMALS
BODY
CADMIUM COMPOUNDS
CADMIUM HALIDES
CARBOHYDRATES
CHLORIDES
CHLORINE COMPOUNDS
DIGESTIVE SYSTEM
ELEMENTS
ENZYMES
ESTERASES
GLANDS
HALIDES
HALOGEN COMPOUNDS
HEXOSES
HYDROLASES
INJECTION
INTAKE
LIGASES
MAMMALS
METALS
MONOSACCHARIDES
ORGANIC COMPOUNDS
ORGANS
RODENTS
SACCHARIDES
SYNTHESIS
VERTEBRATES
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)