Immunity to herpes simplex virus type 2. Suppression of virus-induced immune responses in ultraviolet B-irradiated mice
Ultraviolet B irradiation (280 to 320 nm) of mice at the site of intradermal infection with herpes simplex virus type 2 increased the severity of the herpes simplex virus type 2 disease and decreased delayed-type hypersensitivity (DTH) responses to viral antigen. Decrease in DTH resulted from the induction of suppressor T cells, as evidenced by the ability of spleen cells from UV-irradiated mice to inhibit DTH and proliferative responses after adoptive transfer. Lymph node cells from UV-irradiated animals did not transfer suppression. DTH was suppressed at the induction but not the expression phase. Suppressor T cells were Lyt-1+, L3T4+, and their activity was antigen-specific. However, after in vitro culture of spleen cells from UV-irradiated mice with herpes simplex virus type 2 antigen, suppressor activity was mediated by Lyt-2+ cells. Culture supernatants contained soluble nonantigen-specific suppressive factors.
- Research Organization:
- Univ. of Maryland School of Medicine, Baltimore
- OSTI ID:
- 5715086
- Journal Information:
- J. Immunol.; (United States), Vol. 139:8
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
HERPES SIMPLEX
IMMUNITY
LYMPHOCYTES
SPECIFICITY
SPLEEN CELLS
CELL PROLIFERATION
ANTIGENS
IMMUNOSUPPRESSION
INHIBITION
LYMPH NODES
MICE
SENSITIVITY
SKIN
ULTRAVIOLET RADIATION
ANIMAL CELLS
ANIMALS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
CONNECTIVE TISSUE CELLS
DISEASES
ELECTROMAGNETIC RADIATION
INFECTIOUS DISEASES
LEUKOCYTES
LYMPHATIC SYSTEM
MAMMALS
MATERIALS
ORGANS
RADIATIONS
RODENTS
SKIN DISEASES
SOMATIC CELLS
VERTEBRATES
VIRAL DISEASES
560152* - Radiation Effects on Animals- Animals