Effect of sodium meclofenamate on radiation-induced esophagitis and cystitis

Journal Article · Sun Jan 01 00:00:00 EST 1984 · J. Med. (Westbury, N.Y.); (United States)

OSTI ID:5707514

Ambrus, J L; Ambrus, C M; Lillie, D B; Johnson, R J; Gastpar, H; Kishel, S

Stumptailed monkeys (Macaca arctoides) received 2000 rad irradiation to the upper half of the esophagus and to the bladder by a 6-MeV linear accelerator. Endoscopy and biopsy was obtained from these organs weekly for 3 weeks. At the end of this period, the animals were autopsied and histopathologic examination undertaken. Sodium meclofenamate in doses of 5-20 mg/kg/day p.os was found effective in reducing or preventing radiation-induced esophagitis and cystitis.

• Research Organization: Roswell Park Memorial Inst., Buffalo, NY
• OSTI ID: 5707514
• Journal Information: J. Med. (Westbury, N.Y.); (United States), Vol. 15:2
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BLADDER
BIOLOGICAL RADIATION EFFECTS
ESOPHAGUS
RADIOPROTECTIVE SUBSTANCES
BIOLOGICAL EFFECTS
ANTIPYRETICS
AUTOPSY
BIOPSY
EXTERNAL IRRADIATION
INFLAMMATION
LINEAR ACCELERATORS
MONKEYS
PATHOLOGY
RADIATION INJURIES
ACCELERATORS
ANIMALS
BODY
CENTRAL NERVOUS SYSTEM DEPRESSANTS
DIAGNOSTIC TECHNIQUES
DIGESTIVE SYSTEM
DRUGS
INJURIES
IRRADIATION
MAMMALS
ORGANS
PATHOLOGICAL CHANGES
PRIMATES
RADIATION EFFECTS
SYMPTOMS
URINARY TRACT
VERTEBRATES
560151* - Radiation Effects on Animals- Man