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Title: Effect of sodium meclofenamate on radiation-induced esophagitis and cystitis

Abstract

Stumptailed monkeys (Macaca arctoides) received 2000 rad irradiation to the upper half of the esophagus and to the bladder by a 6-MeV linear accelerator. Endoscopy and biopsy was obtained from these organs weekly for 3 weeks. At the end of this period, the animals were autopsied and histopathologic examination undertaken. Sodium meclofenamate in doses of 5-20 mg/kg/day p.os was found effective in reducing or preventing radiation-induced esophagitis and cystitis.

Authors:
; ; ; ; ;
Publication Date:
Research Org.:
Roswell Park Memorial Inst., Buffalo, NY
OSTI Identifier:
5707514
Resource Type:
Journal Article
Journal Name:
J. Med. (Westbury, N.Y.); (United States)
Additional Journal Information:
Journal Volume: 15:2
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; BLADDER; BIOLOGICAL RADIATION EFFECTS; ESOPHAGUS; RADIOPROTECTIVE SUBSTANCES; BIOLOGICAL EFFECTS; ANTIPYRETICS; AUTOPSY; BIOPSY; EXTERNAL IRRADIATION; INFLAMMATION; LINEAR ACCELERATORS; MONKEYS; PATHOLOGY; RADIATION INJURIES; ACCELERATORS; ANIMALS; BODY; CENTRAL NERVOUS SYSTEM DEPRESSANTS; DIAGNOSTIC TECHNIQUES; DIGESTIVE SYSTEM; DRUGS; INJURIES; IRRADIATION; MAMMALS; ORGANS; PATHOLOGICAL CHANGES; PRIMATES; RADIATION EFFECTS; SYMPTOMS; URINARY TRACT; VERTEBRATES; 560151* - Radiation Effects on Animals- Man

Citation Formats

Ambrus, J.L., Ambrus, C.M., Lillie, D.B., Johnson, R.J., Gastpar, H., and Kishel, S. Effect of sodium meclofenamate on radiation-induced esophagitis and cystitis. United States: N. p., 1984. Web.
Ambrus, J.L., Ambrus, C.M., Lillie, D.B., Johnson, R.J., Gastpar, H., & Kishel, S. Effect of sodium meclofenamate on radiation-induced esophagitis and cystitis. United States.
Ambrus, J.L., Ambrus, C.M., Lillie, D.B., Johnson, R.J., Gastpar, H., and Kishel, S. Sun . "Effect of sodium meclofenamate on radiation-induced esophagitis and cystitis". United States.
@article{osti_5707514,
title = {Effect of sodium meclofenamate on radiation-induced esophagitis and cystitis},
author = {Ambrus, J.L. and Ambrus, C.M. and Lillie, D.B. and Johnson, R.J. and Gastpar, H. and Kishel, S.},
abstractNote = {Stumptailed monkeys (Macaca arctoides) received 2000 rad irradiation to the upper half of the esophagus and to the bladder by a 6-MeV linear accelerator. Endoscopy and biopsy was obtained from these organs weekly for 3 weeks. At the end of this period, the animals were autopsied and histopathologic examination undertaken. Sodium meclofenamate in doses of 5-20 mg/kg/day p.os was found effective in reducing or preventing radiation-induced esophagitis and cystitis.},
doi = {},
journal = {J. Med. (Westbury, N.Y.); (United States)},
number = ,
volume = 15:2,
place = {United States},
year = {1984},
month = {1}
}