Radiation response of an intraspecific somatic ell hybrid (L5178Y, X-ray resistant line x L5178Y, X-ray sensitive line)

Journal Article · Wed Aug 01 00:00:00 EDT 1979 · Radiat. Res.; (United States)

DOI:https://doi.org/10.2307/3575100· OSTI ID:5705933

Dale, B

The radiosensitivities of an x-ray-sensitive L5178Y line, an x-ray-resistant L5178Y line, and of two hybrid lines produced by their fusion have been studied. The hybrid cells are similar in x-ray resistance to the more resistant parent. There was no significant difference in the extrapolation number of the survival curves nor in the ability of the parental and hybrid cells to recover from sublethal damage in dose-fractionation experiments. The radiosensitivities of tetraploid sublines of the two diploid parental lines were also studied and it was shown that the resistance of the hybrid cells is not related to the increase in chromosome number, interaction between the two genomes being ultimately responsible.

• Research Organization: Christie Hospital and Holt Radium Inst., Manchester, England
• OSTI ID: 5705933
• Journal Information: Radiat. Res.; (United States), Vol. 79:2
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
CELL CULTURES
HYBRIDIZATION
RADIOSENSITIVITY
CHROMOSOMES
MICE
POLYPLOIDY
SURVIVAL CURVES
X RADIATION
ANIMALS
ELECTROMAGNETIC RADIATION
IONIZING RADIATIONS
MAMMALS
PLOIDY
RADIATIONS
RODENTS
VERTEBRATES
560121* - Radiation Effects on Cells- External Source- (-1987)