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Title: Cellulose binding domain fusion proteins

Patent ·
OSTI ID:570388
; ; ; ;

A cellulose binding domain (CBD) having a high affinity for crystalline cellulose and chitin is disclosed, along with methods for the molecular cloning and recombinant production. Fusion products comprising the CBD and a second protein are likewise described. A wide range of applications are contemplated for both the CBD and the fusion products, including drug delivery, affinity separations, and diagnostic techniques. 16 figs.

Research Organization:
Univ. of California (United States)
Sponsoring Organization:
USDOE, Washington, DC (United States)
DOE Contract Number:
FG03-92ER20069
Assignee:
Yissum Research Development Co., Jerusalem (Israel); Univ. of California, Oakland, CA (United States)
Patent Number(s):
US 5,719,044/A/
Application Number:
PAN: 8-460,457
OSTI ID:
570388
Resource Relation:
Other Information: PBD: 17 Feb 1998
Country of Publication:
United States
Language:
English

References (28)

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Nucleotide sequence of rat hsp60 (chaperonin, GroEL homolog) cDNA journal January 1990
Fusion to an endoglucanase allows alkaline phosphatase to bind to cellulose journal February 1989
celA from Bacillus lautus PL236 encodes a novel cellulose-binding endo-beta-1,4-glucanase. journal January 1992
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Gene sequence and properties of Cell, a family E endoglucanase from Clostridium thermocellum journal February 1993
Nucleotide sequence of a gene from Caldocellum saccharolyticum encoding for exocellulase and endocellulase activity journal January 1989
Trends in biochemistry and enzymology of cellulose degradation journal November 1990
Chitinase from Serratia marcescens book January 1988
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Immobilized endo-.beta.-glucosidase enriches flavor of wine and passion fruit juice journal June 1990
Sequencing of a Clostridium thermocellum gene (cipA) encoding the cellulosomal S L -protein reveals an unusual degree of internal homology journal April 1993
Homologous plant and bacterial proteins chaperone oligomeric protein assembly journal May 1988
Primary sequence analysis of Clostridium cellulovorans cellulose binding protein A. journal April 1992
A mycobacterial 65-kD heat shock protein induces antigen-specific suppression of adjuvant arthritis, but is not itself arthritogenic. journal January 1990
Synovial fluid-derivedYersinia-reactive T cells responding to human 65-kDa heat-shock protein and heat-stressed antigen-presenting cells journal September 1991
Cloning of the mycobacterial epitope recognized by T lymphocytes in adjuvant arthritis journal January 1988
Immobilization and purification of enzymes with staphylococcal protein A gene fusion vectors. journal April 1985
Essential 170-kDa subunit for degradation of crystalline cellulose by Clostridium cellulovorans cellulase. journal March 1990
Structure of a Bacillus subtilis endo-β-l,4-glucanase gene journal January 1986
The Mycobacterium tuberculosis 65-kilodalton antigen is a heat shock protein which corresponds to common antigen and to the Escherichia coli GroEL protein. journal January 1988
Heat-Shock Proteins as Immunogenic Bacterial Antigens with the Potential to Induce and Regulate Autoimmune Arthritis journal June 1991
Cloning of Clostridiumcellulovoransendo-1,4-β-glucanase genes journal June 1990
Primary structure of a human mitochondrial protein homologous to the bacterial and plant chaperonins and to the 65-kilodalton mycobacterial antigen. journal May 1989
Induction and therapy of autoimmune diabetes in the non-obese diabetic (NOD/Lt) mouse by a 65-kDa heat shock protein. journal February 1990
Molecular cloning of a Chinese hamster mitochondrial protein related to the “chaperonin” family of bacterial and plant proteins journal July 1989
Non–Hydrolytic Disruption of Cellulose Fibres by the Binding Domain of a Bacterial Cellulase journal November 1991

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Related Subjects

55 BIOLOGY AND MEDICINE
BASIC STUDIES
CELLULOSE
RECEPTORS
DNA-CLONING
AFFINITY
RECOMBINANT DNA
PROTEINS
DRUGS