Radiosensitivity of progenitor cells of the hematopoietic microenvironment. [Comparison in vitro and in vivo]
The radiosensitivity of cells which transfer hematopoietic microenvironment was studied in a model in which femoral bone marrow is transplanted under the renal capsule of a mouse. For in vitro /sup 137/Cs ..gamma.. irradiation, the D/sub o/ for the hamatopoietic microenvvironment transferring units (HMTU) was 444 +- 5 rad and the extrapolation number (n) was 5.2. The value of the quasi-threshold dose (D/sub q/) was approximately 500 rad which reflects the high capacity of HMTU for repair of sublethal injury. After in vivo exposure to ..gamma.. rays, HMTU radiosensitivity was somewhat higher (D/sub o/ of 325 +- 25 rad, n of 3.5, and D/sub q/ of 635 rad). For in vitro irradiation with fast neutrons, the D/sub o/ was 161 +- 19 rad and n, 1.4. On the basis of the fraction of transplant failures after exposure to different radiation doses it was calculated that one femoral marrow plug contains about 50 HMTU.
- Research Organization:
- Central Inst. of Hematology and Blood Transfusion, Moscow, USSR
- OSTI ID:
- 5685949
- Journal Information:
- Radiat. Res.; (United States), Vol. 19:1
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
BONE MARROW CELLS
RADIOSENSITIVITY
CFU
STEM CELLS
CELL CULTURES
CESIUM 137
COMPARATIVE EVALUATIONS
EXPERIMENTAL DATA
EXTERNAL IRRADIATION
FAST NEUTRONS
GAMMA RADIATION
IN VITRO
IN VIVO
ISOLATED VALUES
MICE
TRANSPLANTS
ALKALI METAL ISOTOPES
ANIMAL CELLS
ANIMALS
BARYONS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
CESIUM ISOTOPES
CONNECTIVE TISSUE CELLS
DATA
DATA FORMS
ELECTROMAGNETIC RADIATION
ELEMENTARY PARTICLES
FERMIONS
HADRONS
INFORMATION
IONIZING RADIATIONS
IRRADIATION
ISOTOPES
MAMMALS
NEUTRONS
NUCLEI
NUCLEONS
NUMERICAL DATA
ODD-EVEN NUCLEI
RADIATIONS
RADIOISOTOPES
RODENTS
SOMATIC CELLS
VERTEBRATES
YEARS LIVING RADIOISOTOPES
560151* - Radiation Effects on Animals- Man
560121 - Radiation Effects on Cells- External Source- (-1987)