Prenatal lead exposure and bone growth. Doctoral thesis
An experimental system of lead (7439921) related prenatal and postnatal growth retardation in rats was developed. Sprague-Dawley-rats and Long-Evans-rats were used in these studies. Rats were exposed to lead in their drinking water at up to 1000 parts per million. A significant effect on fetal bone mineralization could not be excluded and there was a definite effect on fetal body weight following maternal lead exposure. Reduced food intake during the first week of lead exposure was the primary determinant of reduced body and skeletal growth in the lead exposed weanling female rats. When maternal lead exposure was continued during lactation a greater degree of lead related growth retardation in rat offspring occurred than when maternal lead exposure was terminated at parturition. Combined prenatal and postnatal lead exposure impaired bone resorption and increased growth plate widths. In studies using matrix induced endochondral bone plaques, locally applied lead enhanced plaque mineralization through comineralization of lead with calcium. When lead was administered in drinking water, plaque mineralization was also enhanced through the comineralization of lead with calcium.
- Research Organization:
- Cincinnati Univ. Medical Center, OH (United States). Inst. of Environmental Health
- OSTI ID:
- 5679149
- Report Number(s):
- PB-92-136258/XAB; CNN: R03-OH-02378-02
- Resource Relation:
- Other Information: Thesis (Ph.D.). Sponsored by National Inst. for Occupational Safety and Health, Cincinnati, OH
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
LEAD
TOXICITY
SKELETON
ANIMAL GROWTH
FETUSES
INHIBITION
MINERALIZATION
PRENATAL EXPOSURE
RATS
TERATOGENESIS
ANIMALS
BODY
ELEMENTS
GROWTH
MAMMALS
METALS
ORGANS
RODENTS
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology