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Title: Chromosomal abnormalities in human sperm

Abstract

The ability to analyze human sperm chromosome complements after penetration of zona pellucida-free hamster eggs provides the first opportunity to study the frequency and type of chromosomal abnormalities in human gametes. Two large-scale studies have provided information on normal men. We have studied 1,426 sperm complements from 45 normal men and found an abnormality rate of 8.9%. Brandriff et al. (5) found 8.1% abnormal complements in 909 sperm from 4 men. The distribution of numerical and structural abnormalities was markedly dissimilar in the 2 studies. The frequency of aneuploidy was 5% in our sample and only 1.6% in Brandriff's, perhaps reflecting individual variability among donors. The frequency of 24,YY sperm was low: 0/1,426 and 1/909. This suggests that the estimates of nondisjunction based on fluorescent Y body data (1% to 5%) are not accurate. We have also studied men at increased risk of sperm chromosomal abnormalities. The frequency of chromosomally unbalanced sperm in 6 men heterozygous for structural abnormalities varied dramatically: 77% for t11;22, 32% for t6;14, 19% for t5;18, 13% for t14;21, and 0% for inv 3 and 7. We have also studied 13 cancer patients before and after radiotherapy and demonstrated a significant dose-dependent increase of sperm chromosomemore » abnormalities (numerical and structural) 36 months after radiation treatment.« less

Authors:
Publication Date:
Research Org.:
Univ. of Calgary, Alberta
OSTI Identifier:
5675602
Resource Type:
Journal Article
Resource Relation:
Journal Name: Basic Life Sci.; (United States)
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; RADIOTHERAPY; SIDE EFFECTS; SPERMATOZOA; CHROMOSOMAL ABERRATIONS; ANEUPLOIDY; GENETIC RADIATION EFFECTS; HETEROCHROMATIN; MEN; NEOPLASMS; OOCYTES; ANIMALS; BIOLOGICAL EFFECTS; BIOLOGICAL RADIATION EFFECTS; CHROMATIN; DISEASES; GAMETES; GENETIC EFFECTS; GERM CELLS; MALES; MAMMALS; MAN; MEDICINE; MUTATIONS; NUCLEAR MEDICINE; PLOIDY; PRIMATES; RADIATION EFFECTS; RADIOLOGY; THERAPY; VERTEBRATES; 560151* - Radiation Effects on Animals- Man

Citation Formats

Martin, R.H.. Chromosomal abnormalities in human sperm. United States: N. p., 1985. Web. doi:10.1007/978-1-4613-2127-9_6.
Martin, R.H.. Chromosomal abnormalities in human sperm. United States. doi:10.1007/978-1-4613-2127-9_6.
Martin, R.H.. Tue . "Chromosomal abnormalities in human sperm". United States. doi:10.1007/978-1-4613-2127-9_6.
@article{osti_5675602,
title = {Chromosomal abnormalities in human sperm},
author = {Martin, R.H.},
abstractNote = {The ability to analyze human sperm chromosome complements after penetration of zona pellucida-free hamster eggs provides the first opportunity to study the frequency and type of chromosomal abnormalities in human gametes. Two large-scale studies have provided information on normal men. We have studied 1,426 sperm complements from 45 normal men and found an abnormality rate of 8.9%. Brandriff et al. (5) found 8.1% abnormal complements in 909 sperm from 4 men. The distribution of numerical and structural abnormalities was markedly dissimilar in the 2 studies. The frequency of aneuploidy was 5% in our sample and only 1.6% in Brandriff's, perhaps reflecting individual variability among donors. The frequency of 24,YY sperm was low: 0/1,426 and 1/909. This suggests that the estimates of nondisjunction based on fluorescent Y body data (1% to 5%) are not accurate. We have also studied men at increased risk of sperm chromosomal abnormalities. The frequency of chromosomally unbalanced sperm in 6 men heterozygous for structural abnormalities varied dramatically: 77% for t11;22, 32% for t6;14, 19% for t5;18, 13% for t14;21, and 0% for inv 3 and 7. We have also studied 13 cancer patients before and after radiotherapy and demonstrated a significant dose-dependent increase of sperm chromosome abnormalities (numerical and structural) 36 months after radiation treatment.},
doi = {10.1007/978-1-4613-2127-9_6},
journal = {Basic Life Sci.; (United States)},
number = ,
volume = ,
place = {United States},
year = {Tue Jan 01 00:00:00 EST 1985},
month = {Tue Jan 01 00:00:00 EST 1985}
}