Genetics of susceptibility for radiation-induced leukemia. Mapping of genes involved to chromosomes 1, 2, and 4, and implications for a viral etiology in the disease. [Mice]

Journal Article · Thu Jan 01 00:00:00 EST 1981 · J. Exp. Med.; (United States)

DOI:https://doi.org/10.1084/jem.154.4.1201· OSTI ID:5672570

Meruelo, D; Offer, M; Flieger, N

Susceptibility to radiation-induced leukemia in (A/J x B10)F2 mice is encoded for by genes in chromosomes 1, 2, and 4. The loci involved in chromosomes 1 and 4 are close to or similar to xenotropic virus inducibility locus on chromosome 1 and a locus-affecting expression of xenotropic MuLV envelope-related cell surface antigens. Radiation-induced leukemia-1 (Ril-1) on chromosome 2 plays an overriding influence in susceptibility to the disease. This locus might encode ecotropic viral-associated genetic information or might contain cellular sequences with oncogenic potential. These findings are of interest in view of the importance of recombinant viruses to leukemogenesis. Furthermore, it is intriguing that Ril-1 is located in a chromosomal site rich in thymus differentiation-specific loci. An explanation for tissue-specific activation of endogenous viruses is that activation of the virus in question is dependent on differentiation-specific steps.

• Research Organization: Department of Pathology, New York University Medical Center, New York
• OSTI ID: 5672570
• Journal Information: J. Exp. Med.; (United States), Vol. 154:4
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
LEUKEMIA
GENETICS
RADIOINDUCTION
LEUKEMIA VIRUSES
RADIOSENSITIVITY EFFECTS
GENETIC MAPPING
MICE
ANIMALS
BIOLOGY
DISEASES
HEMIC DISEASES
MAMMALS
MAPPING
MICROORGANISMS
NEOPLASMS
ONCOGENIC VIRUSES
PARASITES
RODENTS
VERTEBRATES
VIRUSES
560152* - Radiation Effects on Animals- Animals