Divalent cation ionophores stimulate resorption and inhibit DNA synthesis in cultured fetal rat bone

Journal Article · Mon Jun 01 00:00:00 EDT 1981 · Science (Washington, D.C.); (United States)

DOI:https://doi.org/10.1126/science.6785885· OSTI ID:5658683

Lorenzo, J A; Raisz, L G

Two divalent cation ionophores, A23187 and Ionomycin, which are selective for calcium, stimulated the resorption of fetal rat long bones in organ culture at 0.1 to 1 micromolar but not at higher concentrations. Both agents inhibited DNA synthesis at concentrations that stimulated resorption. These results might explain the differences in ionophore effects on bone previously reported, and they imply that cell replication is not required for osteoclast formation in fetal rat long bone cultures.

• OSTI ID: 5658683
• Journal Information: Science (Washington, D.C.); (United States), Vol. 212:4499
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
CATIONS
BIOLOGICAL EFFECTS
SKELETON
PHYSIOLOGY
BIOSYNTHESIS
CALCIUM
CONNECTIVE TISSUE CELLS
DNA
FETUSES
INHIBITION
RATS
TISSUE CULTURES
ALKALINE EARTH METALS
ANIMAL CELLS
ANIMALS
BODY
CHARGED PARTICLES
ELEMENTS
IONS
MAMMALS
METALS
NUCLEIC ACIDS
ORGANIC COMPOUNDS
ORGANS
RODENTS
SOMATIC CELLS
SYNTHESIS
VERTEBRATES
551000* - Physiological Systems