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Title: Metal-binding abilities of radioprotective aminoalkyl disulfides and thiosulfates

Abstract

Metal-binding stability constant for several heterocyclic aminoalkyl disulfides and thiosulfates with Ni (II) and Al (III) were determined. The data obtained indicated that both classes of compounds were acting as bidentate chelating agents and that the heterocyclic rings apparently prevented tridentate behavior of the disulfides because of steric hindrance. The magnitude of the constants indicated that metal complexes of these compounds could exist in a cellular environment, but no correlation with radiation-protective activity was apparent.

Authors:
;
Publication Date:
Research Org.:
Massachusetts Coll. of Pharmacy, Boston
OSTI Identifier:
5654359
Resource Type:
Journal Article
Journal Name:
J. Pharm. Sci.; (United States)
Additional Journal Information:
Journal Volume: 68:2
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; ALUMINIUM; COMPLEXES; RADIOSENSITIVITY EFFECTS; NICKEL; RADIOPROTECTIVE SUBSTANCES; CHEMICAL BONDS; CHELATING AGENTS; CHEMICAL PROPERTIES; DISULFIDES; STABILITY; THIOSULFATES; DRUGS; ELEMENTS; METALS; ORGANIC COMPOUNDS; ORGANIC SULFUR COMPOUNDS; TRANSITION ELEMENTS; 560151* - Radiation Effects on Animals- Man

Citation Formats

Foye, W.O., and Hu, J.M. Metal-binding abilities of radioprotective aminoalkyl disulfides and thiosulfates. United States: N. p., 1979. Web. doi:10.1002/jps.2600680221.
Foye, W.O., & Hu, J.M. Metal-binding abilities of radioprotective aminoalkyl disulfides and thiosulfates. United States. doi:10.1002/jps.2600680221.
Foye, W.O., and Hu, J.M. Thu . "Metal-binding abilities of radioprotective aminoalkyl disulfides and thiosulfates". United States. doi:10.1002/jps.2600680221.
@article{osti_5654359,
title = {Metal-binding abilities of radioprotective aminoalkyl disulfides and thiosulfates},
author = {Foye, W.O. and Hu, J.M.},
abstractNote = {Metal-binding stability constant for several heterocyclic aminoalkyl disulfides and thiosulfates with Ni (II) and Al (III) were determined. The data obtained indicated that both classes of compounds were acting as bidentate chelating agents and that the heterocyclic rings apparently prevented tridentate behavior of the disulfides because of steric hindrance. The magnitude of the constants indicated that metal complexes of these compounds could exist in a cellular environment, but no correlation with radiation-protective activity was apparent.},
doi = {10.1002/jps.2600680221},
journal = {J. Pharm. Sci.; (United States)},
number = ,
volume = 68:2,
place = {United States},
year = {1979},
month = {2}
}