Comparative behavioral toxicity of four sulfhydryl radioprotective compounds in mice: Wr2721, cysteamine, diethyldithiocarbamate, and n-acetylcysteine
A number of sulfhydryl compounds have been shown to protect against ionizing radiation. One of the most effective radioprotectors is S-2(3-aminopropylamino)ethylphosphorothioic acid, also known aas ethiofos, gammaphos, or WR-2721 (Davidson, 1980; Giambarresi and Jacobs, 1987). This drug is currently under clinical investigation for its potential in protecting normal tissue during radiation treatment and chemotherapy (Blumberg et al., 1982; Glover et al., 1988; Yuhas et al., 1980). B-Mercaptoethylamine (MEA, cysteamine) was for years the standard against which the effectiveness of other radioprotectors was judged, but is more toxic than WR-2721 (Giambarresi and Jacobs, 1987). Diethyldithiocarbamate (DDC) and N-acetylcysteine (NAC) are other compounds shown to have radioprotective properties (Milas et al., 1988; Weiss et al., 1984). Studies in a variety of animal species have shown significant behavioral toxicity after administration of WR-2721 (Bogo et al., 1985; Bogo, 1988; Landauer et al., 1987b, 1988).
- Research Organization:
- Armed Forces Radiobiology Research Inst., Bethesda, MD (USA)
- OSTI ID:
- 5646087
- Report Number(s):
- AD-A-208283/2/XAB; AFRRI-SR-89-7
- Resource Relation:
- Other Information: Pub. in Pharmacology and Therapeutics, Vol. 39, 97-100(1988)
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
IONIZING RADIATIONS
RADIOPROTECTIVE SUBSTANCES
ORGANIC SULFUR COMPOUNDS
RADIOTHERAPY
SULFHYDRYL RADICALS
AMINES
ANIMALS
BEHAVIOR
CHEMOTHERAPY
MEA
MICE
TOXICITY
DRUGS
MAMMALS
MEDICINE
NUCLEAR MEDICINE
ORGANIC COMPOUNDS
RADIATIONS
RADICALS
RADIOLOGY
RODENTS
THERAPY
THIOLS
VERTEBRATES
560152* - Radiation Effects on Animals- Animals