A case-control study of lung cancer risk factors in Xuanwei, China

Title: A case-control study of lung cancer risk factors in Xuanwei, China

Full Record
Other Related Research

Abstract

In Xuanwei County, Yunnan Province, mortality rates of lung cancer are among China's highest. Previous studies have shown a strong association between lung cancer mortality and indoor air pollution from smoky coal combustion. In the present case-control study, 110 newly diagnosed lung cancer patients and 426 controls were matched with respect to age, sex, occupation (all subjects were farmers), and village of residence (which provided matching with respect to fuel use). This design allowed assessment of known and suspected lung cancer risk factors other than those mentioned above. Data from males and females were analyzed by conditional logistic regression. In females who do not smoke, the presence of lung cancer was statistically significantly associated with chronic bronchitis and family history of lung cancer. These results also suggested an association of long cancer with duration of cooking food but not with passive smoking. In males, lung cancer was significantly associated with smoking, chronic bronchitis, family history of lung cancer, and personal history of cooking food. Effects of smoking and chronic bronchitis in males were independent, which suggests that lung cancer in Xuanwei may occur through more than one mechanism of production.

Authors:

Zhiyuan, Liu; Xingzhou, He ^[1]; Chapman, R S ^[2]

Chinese Academy of Preventive Medicine, Beijing (China)
U.S. Environmental Protection Agency, Research Triangle Park, NC (USA)

OSTI Identifier:: 5642567

Report Number(s):: CONF-890937-
Journal ID: ISSN 0003-9896; CODEN: AEHLA

Resource Type:: Conference

Journal Name:: Archives of Environmental Health; (USA)

Additional Journal Information:: Journal Volume: 45:5; Conference: 1. annual meeting of the International Society for Environmental Epidemiology, Upton, NY (USA), 13-15 Sep 1989; Journal ID: ISSN 0003-9896

Country of Publication:: United States

Language:: English

Subject:: 59 BASIC BIOLOGICAL SCIENCES; 54 ENVIRONMENTAL SCIENCES; INDOOR AIR POLLUTION; HEALTH HAZARDS; CHINA; COAL; EPIDEMIOLOGY; MAN; NEOPLASMS; RESPIRATORY SYSTEM DISEASES; TOBACCO SMOKES; AEROSOLS; AIR POLLUTION; ANIMALS; ASIA; CARBONACEOUS MATERIALS; COLLOIDS; DISEASES; DISPERSIONS; ENERGY SOURCES; FOSSIL FUELS; FUELS; HAZARDS; MAMMALS; MATERIALS; POLLUTION; PRIMATES; RESIDUES; SMOKES; SOLS; VERTEBRATES; 550900* - Pathology; 540110

Citation Formats


                    Zhiyuan, Liu, Xingzhou, He, and Chapman, R S. A case-control study of lung cancer risk factors in Xuanwei, China.  United States: N. p.,  
        Web.

Copy to clipboard


                    Zhiyuan, Liu, Xingzhou, He, & Chapman, R S. A case-control study of lung cancer risk factors in Xuanwei, China.  United States.

Copy to clipboard


                    Zhiyuan, Liu, Xingzhou, He, and Chapman, R S. .  
        "A case-control study of lung cancer risk factors in Xuanwei, China".  United States.

Copy to clipboard


                    
@article{osti_5642567,

  title        = {A case-control study of lung cancer risk factors in Xuanwei, China},

  author       = {Zhiyuan, Liu and Xingzhou, He and Chapman, R S},

  abstractNote = {In Xuanwei County, Yunnan Province, mortality rates of lung cancer are among China's highest. Previous studies have shown a strong association between lung cancer mortality and indoor air pollution from smoky coal combustion. In the present case-control study, 110 newly diagnosed lung cancer patients and 426 controls were matched with respect to age, sex, occupation (all subjects were farmers), and village of residence (which provided matching with respect to fuel use). This design allowed assessment of known and suspected lung cancer risk factors other than those mentioned above. Data from males and females were analyzed by conditional logistic regression. In females who do not smoke, the presence of lung cancer was statistically significantly associated with chronic bronchitis and family history of lung cancer. These results also suggested an association of long cancer with duration of cooking food but not with passive smoking. In males, lung cancer was significantly associated with smoking, chronic bronchitis, family history of lung cancer, and personal history of cooking food. Effects of smoking and chronic bronchitis in males were independent, which suggests that lung cancer in Xuanwei may occur through more than one mechanism of production.},

  doi          = {},

  url          = {https://www.osti.gov/biblio/5642567},
  journal      = {Archives of Environmental Health; (USA)},

  issn         = {0003-9896},

  number       = ,

  volume       = 45:5,

  place        = {United States},

  year         = {},

  month        = {}

}

Copy to clipboard

Conference:

Other availability

Please see Document Availability for additional information on obtaining the full-text document. Library patrons may search WorldCat to identify libraries that hold this conference proceeding.

Save / Share:

Export Metadata

Save to My Library

Similar records in OSTI.GOV collections:

Risk factors for lung cancer in non-smokers in Xuanwei County of China

Journal Article Lan, Q ; Chen, W ; Chen, H ; ... - Biomedical and Environmental Sciences; (United States)

Tobacco smoking and some types of occupational exposures have consistently been considered as important etiologic factors of lung cancer in industrial countries. At the First World Conference of Lung Cancer (Wyndwer, 1983), it was stressed that more attention should be paid to finding out the causes of lung cancer in non-smokers. In Xuanwei County, Yunnan Province, annual lung cancer death rate was 27.7 per 100,000 in males, among China's highest, and 25.3 per 100,000 in females, the China's highest. The female's lung cancer death rate in Xuanwei County was even much higher than that of the same period in USAmore »« less
An epidemiology study on exposure-response relationship between B(a)P concentration in indoor air and lung cancer mortality in Xuanwei County, China

Conference Xingzhou, He ; Chen, Wei

In Xuanwei County, Yunnan Province, lung cancer mortality is among China's highest, especially in females. (Cigarette smoking is rare in females). The country has 20 communes, each with a population of about 30,000 to 60,000. Lung cancer mortality is varied in the country from 0 to 151.8/10,000. Xuanwei residents use three fuels: (1) smoky coal, (2) wood, and (3) smokeless coal. Because of heavy indoor pollution caused by smoky coal burning, in 1986, we developed a risk assessment by measuring B(a)P concentrations in the indoor smoke caused by fuel burning in 11 communes. Our results showed that the lung cancermore »« less
Variation in lung cancer risk by smoky coal subtype in Xuanwei, China

Journal Article Lan, Q ; He, X Z ; Shen, M ; ... - International Journal of Cancer

Lung cancer rates in Xuanwei County have been among the highest in China for both males and females and have been causally associated with exposure to indoor smoky (bituminous) coal emissions that contain very high levels of polycyclic aromatic hydrocarbons. There are numerous coal mines across the County. Although lung cancer risk is strongly associated with the use of smoky coal as a whole, variation in risk by smoky coal subtype has not been characterized as yet. We conducted a population-based case-control study of 498 lung cancer cases and 498 controls, individually matched to case subjects on age and sexmore »« less
https://doi.org/10.1002/ijc.23748
Tuberculosis and subsequent risk of lung cancer in Xuanwei, China

Journal Article Engels, E A ; Shen, M ; Chapman, R S ; ... - International Journal of Cancer

Tobacco and indoor air pollution from smoky coal are major causes of lung cancer in rural Xuanwei County, China. Tuberculosis has been suggested to increase lung cancer risk, but data from prior studies are limited. We conducted an analysis of data from a retrospective cohort study of 42,422 farmers in Xuanwei. In 1992, interviewers administered a standardized questionnaire that included lifetime medical history, including tuberculosis. Subjects were followed from 1976, with deaths from lung cancer ascertained through 1996. We used proportional hazards regression to assess the association between tuberculosis and subsequent lung cancer mortality. Tuberculosis was reported by 246 subjectsmore »« less
https://doi.org/10.1002/ijc.24042
Coal use, stove improvement, and adult pneumonia mortality in Xuanwei, China: a retrospective cohort study

Journal Article Shen, M ; Chapman, R S ; Vermeulen, R ; ... - Environmental Health Perspectives

In Xuanwei County, China, unvented indoor coal burning is strongly associated with increased risk of lung cancer and chronic obstructive pulmonary disease. However, the impact of coal burning and stove improvement on risk of pneumonia is not clear. We conducted a retrospective cohort study among all farmers born 1917 through 1951 and living in Xuanwei as of 1 January 1976. The analysis included a total of 42,422 cohort members. Follow-up identified all deaths in the cohort from 1976 through 1996. Ages at entry into and at exit from follow-up ranged from 24 to 59 years and from 25 to 80more »« less
https://doi.org/10.1289/ehp.11521

Similar Records