Pathologic effects of fractionated fast neutrons or photons on canine liver
Thirty-nine adult male purebred beagles received either fast neutron or photon irradiation to the right thorax to determine the effects on pulmonary tissue. The right half of the liver was included in the field of radiation. Twenty-four dogs (six/group) received fast neutrons with a mean energy of 15 MeV to total doses of 1000, 1500, 2250, or 3375 rads in four fractions per week for 6 weeks. Fifteen dogs received 3000, 4500, or 6750 total rads of photons (five dogs/group) in an identical fractionation pattern. All neutron-irradiated dogs receiving 3375 and 2250 rads and one receiving 1500 rads developed clinical signs, hepatic enzyme, and bilirubin elevations, and the dogs died or were euthanized in extremis on postirradiation day 47-291. Signs of liver injury, other than enzyme changes, have not developed to date (1200-1300 days) in the remaining dogs, except in one 6750-rad photon dog that died of hepatic failure on postirradiation day 708. At necropsy, the irradiated right lobes of the liver were atrophic and the nonirradiated left lobes underwent compensatory hypertrophy. Hepatic arterioles and bile ducts were injured in every dog, but no obstructive lesions were observed in hepatic veins. Portal fibroplasia, bile retention, and proliferation of bile ductules was common; the latter two changes also occurred in the nonirradiated lobes. No qualitative differences were observed between hepatic lesions in neutron- versus photon-irradiated dogs. The relative biological effectiveness of fast neutrons for liver damage appears to be no less than 4.5.
- OSTI ID:
- 5635669
- Journal Information:
- Cancer Clin. Trials; (United States), Vol. 4:1
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
59 BASIC BIOLOGICAL SCIENCES
BILIARY TRACT
BIOLOGICAL RADIATION EFFECTS
LIVER
LUNGS
ATROPHY
BEAGLES
ENZYME ACTIVITY
FAST NEUTRONS
FRACTIONATED IRRADIATION
HYPERTROPHY
PARTIAL BODY IRRADIATION
PHOTONS
RADIATION DOSES
RADIOSENSITIVITY
RBE
ANIMALS
BARYONS
BIOLOGICAL EFFECTS
BODY
DIGESTIVE SYSTEM
DOGS
DOSES
ELEMENTARY PARTICLES
EXTERNAL IRRADIATION
FERMIONS
GLANDS
HADRONS
IRRADIATION
MAMMALS
MASSLESS PARTICLES
NEUTRONS
NUCLEONS
ORGANS
PATHOLOGICAL CHANGES
RADIATION EFFECTS
RESPIRATORY SYSTEM
VERTEBRATES
560152* - Radiation Effects on Animals- Animals
550900 - Pathology