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Title: Percutaneous absorption of topically applied DTIC-14C (NSC-45388) in Yorkshire white pigs. Final report, 14 September-14 November 1976

Abstract

The absorption of topically applied DTIC (5-(3,3-dimethyl-1-triazeno) imidazole-4-carboxamide-2-14C) (NSC-45388) was studied in female, weanling, Yorkshire white pigs. After 48 hours, an average of 9.61% of the topically applied dose was excreted in the urine of the test animals. Liver and kidney showed the most consistent uptake of radioactivity with heart and adrenal samples also showing significant uptake. Radioactivity was detected in random muscle samples at 6 hours after application, and in bone after 48 hours. A significant percentage of the applied dose was generally detected at and near the site of application.

Authors:
; ; ; ;
Publication Date:
Research Org.:
Battelle Columbus Toxicology Program Office, McLean, VA (USA); Mississippi Univ., University (USA). Research Inst. of Pharmaceutical Sciences
OSTI Identifier:
5634334
Report Number(s):
PB-290429
TRN: 80-001331
DOE Contract Number:  
N01-CM-4-3746
Resource Type:
Technical Report
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; 62 RADIOLOGY AND NUCLEAR MEDICINE; ANTINEOPLASTIC DRUGS; SKIN ABSORPTION; TISSUE DISTRIBUTION; CARBON 14 COMPOUNDS; EXCRETION; SWINE; TRACER TECHNIQUES; URINE; ANIMALS; BIOLOGICAL MATERIALS; BIOLOGICAL WASTES; BODY FLUIDS; CLEARANCE; DISTRIBUTION; DOMESTIC ANIMALS; DRUGS; ISOTOPE APPLICATIONS; LABELLED COMPOUNDS; MAMMALS; UPTAKE; VERTEBRATES; WASTES; 551001* - Physiological Systems- Tracer Techniques; 550600 - Medicine

Citation Formats

Skierkowski, P., Murphy, J.C., Watson, E.S., Folk, R.M., and Pavkov, K.L. Percutaneous absorption of topically applied DTIC-14C (NSC-45388) in Yorkshire white pigs. Final report, 14 September-14 November 1976. United States: N. p., 1978. Web.
Skierkowski, P., Murphy, J.C., Watson, E.S., Folk, R.M., & Pavkov, K.L. Percutaneous absorption of topically applied DTIC-14C (NSC-45388) in Yorkshire white pigs. Final report, 14 September-14 November 1976. United States.
Skierkowski, P., Murphy, J.C., Watson, E.S., Folk, R.M., and Pavkov, K.L. Wed . "Percutaneous absorption of topically applied DTIC-14C (NSC-45388) in Yorkshire white pigs. Final report, 14 September-14 November 1976". United States.
@article{osti_5634334,
title = {Percutaneous absorption of topically applied DTIC-14C (NSC-45388) in Yorkshire white pigs. Final report, 14 September-14 November 1976},
author = {Skierkowski, P. and Murphy, J.C. and Watson, E.S. and Folk, R.M. and Pavkov, K.L.},
abstractNote = {The absorption of topically applied DTIC (5-(3,3-dimethyl-1-triazeno) imidazole-4-carboxamide-2-14C) (NSC-45388) was studied in female, weanling, Yorkshire white pigs. After 48 hours, an average of 9.61% of the topically applied dose was excreted in the urine of the test animals. Liver and kidney showed the most consistent uptake of radioactivity with heart and adrenal samples also showing significant uptake. Radioactivity was detected in random muscle samples at 6 hours after application, and in bone after 48 hours. A significant percentage of the applied dose was generally detected at and near the site of application.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Wed Mar 01 00:00:00 EST 1978},
month = {Wed Mar 01 00:00:00 EST 1978}
}

Technical Report:
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