In vivo evaluation of Z-(R,R)-IQNP as a candidate for the study of M{sub 2} muscarinic receptors by SPECT

Journal Article · Thu May 01 00:00:00 EDT 1997 · Journal of Nuclear Medicine

OSTI ID:563340

McPherson, D W; Greenbaum, M; Beets, A L ^[1]

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1. Oak Ridge National Lab., TN (United States); and others

The ability to image alternations of M{sub 2} muscarinic receptors is of importance in the study of dementias and heart failure. We have developed a QNB analogue, Z-(R)-1-azabicyclo[2.2.2]oct-3-yl (R)-alpha-hydroxy-alpha-(1-iodo-1-propen-3-yl)-alpha-phenylacetate (Z-(R,R)-IQNP), which demonstrates high in vitro binding affinity for both the M{sub 1} and M{sub 2} muscarinic receptor subtypes.

• DOE Contract Number: AC05-96OR22464
• OSTI ID: 563340
• Report Number(s): CONF-970602-; ISSN 0161-5505; TRN: 97:004028-0012
• Journal Information: Journal of Nuclear Medicine, Vol. 38, Issue Suppl.5; Conference: 44. annual meeting of the Society of Nuclear Medicine, San Antonio, TX (United States), 2-5 Jun 1997; Other Information: PBD: May 1997
• Country of Publication: United States
• Language: English

Related Subjects

55 BIOLOGY AND MEDICINE
BASIC STUDIES
MENTAL DISORDERS
DIAGNOSTIC TECHNIQUES
CARDIOVASCULAR DISEASES
ACETATES
AFFINITY
METABOLISM
ORGANIC IODINE COMPOUNDS
IMAGES
BRAIN
HEART
IODINE 125
LABELLED COMPOUNDS
HYDROXY COMPOUNDS