In vivo evaluation of Z-(R,R)-IQNP as a candidate for the study of M{sub 2} muscarinic receptors by SPECT
Journal Article
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· Journal of Nuclear Medicine
OSTI ID:563340
- Oak Ridge National Lab., TN (United States); and others
The ability to image alternations of M{sub 2} muscarinic receptors is of importance in the study of dementias and heart failure. We have developed a QNB analogue, Z-(R)-1-azabicyclo[2.2.2]oct-3-yl (R)-alpha-hydroxy-alpha-(1-iodo-1-propen-3-yl)-alpha-phenylacetate (Z-(R,R)-IQNP), which demonstrates high in vitro binding affinity for both the M{sub 1} and M{sub 2} muscarinic receptor subtypes.
- DOE Contract Number:
- AC05-96OR22464
- OSTI ID:
- 563340
- Report Number(s):
- CONF-970602-; ISSN 0161-5505; TRN: 97:004028-0012
- Journal Information:
- Journal of Nuclear Medicine, Vol. 38, Issue Suppl.5; Conference: 44. annual meeting of the Society of Nuclear Medicine, San Antonio, TX (United States), 2-5 Jun 1997; Other Information: PBD: May 1997
- Country of Publication:
- United States
- Language:
- English
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