Overview of PSB track on gene structure identification in large-scale genomic sequence
The recent funding of more than a dozen major genome centers to begin community-wide high-throughput sequencing of the human genome has created a significant new challenge for the computational analysis of DNA sequence and the prediction of gene structure and function. It has been estimated that on average from 1996 to 2003, approximately 2 million bases of newly finished DNA sequence will be produced every day and be made available on the Internet and in central databases. The finished (fully assembled) sequence generated each day will represent approximately 75 new genes (and their respective proteins), and many times this number will be represented in partially completed sequences. The information contained in these is of immeasurable value to medical research, biotechnology, the pharmaceutical industry and researchers in a host of fields ranging from microorganism metabolism, to structural biology, to bioremediation. Sequencing of microorganisms and other model organisms is also ramping up at a very rapid rate. The genomes for yeast and several microorganisms such as H. influenza have recently been fully sequenced, although the significance of many genes remains to be determined.
- Research Organization:
- Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
- Sponsoring Organization:
- USDOE Office of Energy Research, Washington, DC (United States)
- DOE Contract Number:
- AC05-96OR22464
- OSTI ID:
- 563242
- Report Number(s):
- ORNL/CP-94807; CONF-980118-; ON: DE98000576; BR: KP1103010; TRN: AHC29803%%79
- Resource Relation:
- Conference: 3. Pacific symposium on biocomputing, Kapalua, HI (United States), 5 Jan 1998; Other Information: PBD: [1998]
- Country of Publication:
- United States
- Language:
- English
Similar Records
Localization of eight additional genes in the human major histocompatibility complex, including the gene encoding the casein kinase II {beta} subunit (CSNK2B)
The Shewanella Federation: Functional Genomic Investigations of Dissimilatory Metal-Reducing Shewanella