Labeling of receptor ligands with bromine radionuclides. Progress report, March 1, 1981-February 29, 1984

Technical Report · Sat Oct 01 00:00:00 EDT 1983

OSTI ID:5623514

Welch, M J

We have developed techniques to label several types of organic molecules with radiobromine. We have emphasized techniques to label ligands for the estrogen receptor and have studied two brominated compounds in rat models. One of these compounds has been studied in a limited number of patients and estrogen containing tumors visualized by nuclear medicine imaging. We have recently expanded the size of the work to label receptor ligands with fluorine-18 and have carried out preliminary animal studies which suggest that a clinically useful compound can be prepared. In addition to the receptor studies, we have collaborated in assessing /sup 77/Br-labeled compounds as therapeutic agents and in studying /sup 77/Br-labeled compounds using perturbed angular correlation techniques.

• Research Organization: Washington Univ., St. Louis, MO (USA). Edward Mallinckrodt Inst. of Radiology
• DOE Contract Number: AC02-81EV10650
• OSTI ID: 5623514
• Report Number(s): DOE/EV/10650-3; ON: DE84001827
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
BROMINE 77
DIAGNOSTIC USES
FLUORINE 18
LIGANDS
LABELLING
BIOLOGICAL MODELS
NEOPLASMS
NUCLEAR MEDICINE
ORGANIC COMPOUNDS
RADIOPHARMACEUTICALS
RATS
RECEPTORS
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BROMINE ISOTOPES
DAYS LIVING RADIOISOTOPES
DISEASES
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
FLUORINE ISOTOPES
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
ISOTOPES
LABELLED COMPOUNDS
LIGHT NUCLEI
MAMMALS
MEDICINE
MINUTES LIVING RADIOISOTOPES
NUCLEI
ODD-EVEN NUCLEI
ODD-ODD NUCLEI
RADIOISOTOPES
RODENTS
USES
VERTEBRATES
550601* - Medicine- Unsealed Radionuclides in Diagnostics