{ital In vivo} bidirectional color Doppler flow imaging of picoliter blood volumes using optical coherence tomography
- Departments of Biomedical Engineering and Medicine, Case Western Reserve University, Cleveland, Ohio 44106 (United States)
- Biomedical Engineering Program, University of Texas at Austin, Austin, Texas 78712 (United States)
We describe a novel optical system for bidirectional color Doppler imaging of flow in biological tissues with micrometer-scale resolution and demonstrate its use for {ital in vivo} imaging of blood flow in an animal model. Our technique, color Doppler optical coherence tomography (CDOCT), performs spatially localized optical Doppler velocimetry by use of scanning low-coherence interferometry. CDOCT is an extension of optical coherence tomography (OCT), employing coherent signal-acquisition electronics and joint time-frequency analysis algorithms to perform flow imaging simultaneous with conventional OCT imaging. Cross-sectional maps of blood flow velocity with {lt}50{minus}{mu}m spatial resolution and {lt}0.6{minus}mm/s velocity precision were obtained through intact skin in living hamster subdermal tissue. This technology has several potential medical applications. {copyright} {ital 1997} {ital Optical Society of America}
- DOE Contract Number:
- FG03-95ER61971
- OSTI ID:
- 560688
- Journal Information:
- Optics Letters, Vol. 22, Issue 18; Other Information: PBD: Sep 1997
- Country of Publication:
- United States
- Language:
- English
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