Precision, high dose radiotherapy: helium ion treatment of uveal melanoma
The authors report on 75 patients with uveal melanoma who were treated by placing the Bragg peak of a helium ion beam over the tumor volume. The technique localizes the high dose region very tightly around the tumor volume. This allows critical structures, such as the optic disc and the macula, to be excluded from the high dose region as long as they are 3 to 4 mm away from the edge of the tumor. Careful attention to tumor localization, treatment planning, patient immobilization and treatment verification is required. With a mean follow-up of 22 months (3 to 60 months) the authors have had only five patients with a local recurrence, all of whom were salvaged with another treatment. Pretreatment visual acuity has generally been preserved as long as the tumor edge is at least 4 mm away from the macula and optic disc. The only serious complication to date has been an 18% incidence of neovascular glaucoma in the patients treated at our highest dose level. Clinical results and details of the technique are presented to illustrate potential clinical precision in administering high dose radiotherapy with charged particles such as helium ions or protons.
- Research Organization:
- Univ. of California, San Francisco
- DOE Contract Number:
- AC03-76SF00098
- OSTI ID:
- 5606193
- Report Number(s):
- CONF-8310342-; TRN: 85-015626
- Journal Information:
- Int. J. Radiat. Oncol., Biol. Phys.; (United States), Vol. 11:2; Conference: 25. annual meeting of the American Society of Therapeutic Radiologists, Los Angeles, CA, USA, 3 Oct 1983
- Country of Publication:
- United States
- Language:
- English
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62 RADIOLOGY AND NUCLEAR MEDICINE
EYES
BIOLOGICAL RADIATION EFFECTS
MELANOMAS
RADIOTHERAPY
SIDE EFFECTS
SENSE ORGANS DISEASES
RADIOINDUCTION
HELIUM
ION BEAMS
PATIENTS
SENSE ORGANS
UVEA
BEAMS
BIOLOGICAL EFFECTS
BODY
BODY AREAS
DISEASES
ELEMENTS
FACE
FLUIDS
GASES
HEAD
MEDICINE
NEOPLASMS
NONMETALS
NUCLEAR MEDICINE
ORGANS
RADIATION EFFECTS
RADIOLOGY
RARE GASES
THERAPY
560151* - Radiation Effects on Animals- Man
550603 - Medicine- External Radiation in Therapy- (1980-)