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Title: Effect of material from alternate energy sources on whole animal defense systems

Abstract

As energy sources and energy production technologies change to adjust to the demands of expanding population, new stresses are generated with respect to the health and life expectancy of the population. Not only will the patterns and character of the emissions from these alternate energy sources be different, but ever-increasing numbers of people will be exposed to these agents for an expanding percentage of their life years. The possibility that inhalation of particles from these alternate energy sources in the size ranges which permit deposition in the deep alveoli (i.e., from approximately two microns to submicron sizes) may result in suble or overt impairment of macrophage function and, subsequently, concommitant alteration in other respiratory defense mechanisms forms the basis for these studies. Such perturbations may, in turn, adversely affect overall particle clearance mechanisms predisposing the host to tissue injury and disease. Animals will be exposed to various doses of these particles and the following parameters will be assayed: (1) ability of alveolar macrophages to function (viability, phagocytosis, respiration numbers, morphology response to macrophage migration inhibition factor, bacteriocidal activity, lysosomal enzymes, and AHH activity); (2) induction of autoimmunity directed against lung tissue; (3) nucleic acid synthesis in alveolar macrophages; and (4)more » cyclic AMP levels in pulmonary tissue. A draft research protocol for fuel and fuel additives will be prepared.« less

Authors:
;
OSTI Identifier:
5605971
Resource Type:
Book
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; PARTICULATES; LUNG CLEARANCE; SYNTHETIC FUELS; BIOLOGICAL EFFECTS; AMP; ENZYME ACTIVITY; HEALTH HAZARDS; HYDROXYLASES; INHALATION; LABORATORY ANIMALS; LUNGS; MACROPHAGES; NUCLEIC ACIDS; PARTICLE SIZE; PHAGOCYTOSIS; RETENTION; RETICULOENDOTHELIAL SYSTEM; ANIMAL CELLS; ANIMAL TISSUES; BODY; CLEARANCE; CONNECTIVE TISSUE CELLS; ENZYMES; EXCRETION; FUELS; HAZARDS; INTAKE; NUCLEOTIDES; ORGANIC COMPOUNDS; ORGANS; OXIDOREDUCTASES; PARTICLES; PHAGOCYTES; RESPIRATORY SYSTEM; SIZE; SOMATIC CELLS; TISSUES; 560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)

Citation Formats

Gause, E, and Graham, J A. Effect of material from alternate energy sources on whole animal defense systems. United States: N. p., Web.
Gause, E, & Graham, J A. Effect of material from alternate energy sources on whole animal defense systems. United States.
Gause, E, and Graham, J A. . "Effect of material from alternate energy sources on whole animal defense systems". United States.
@article{osti_5605971,
title = {Effect of material from alternate energy sources on whole animal defense systems},
author = {Gause, E and Graham, J A},
abstractNote = {As energy sources and energy production technologies change to adjust to the demands of expanding population, new stresses are generated with respect to the health and life expectancy of the population. Not only will the patterns and character of the emissions from these alternate energy sources be different, but ever-increasing numbers of people will be exposed to these agents for an expanding percentage of their life years. The possibility that inhalation of particles from these alternate energy sources in the size ranges which permit deposition in the deep alveoli (i.e., from approximately two microns to submicron sizes) may result in suble or overt impairment of macrophage function and, subsequently, concommitant alteration in other respiratory defense mechanisms forms the basis for these studies. Such perturbations may, in turn, adversely affect overall particle clearance mechanisms predisposing the host to tissue injury and disease. Animals will be exposed to various doses of these particles and the following parameters will be assayed: (1) ability of alveolar macrophages to function (viability, phagocytosis, respiration numbers, morphology response to macrophage migration inhibition factor, bacteriocidal activity, lysosomal enzymes, and AHH activity); (2) induction of autoimmunity directed against lung tissue; (3) nucleic acid synthesis in alveolar macrophages; and (4) cyclic AMP levels in pulmonary tissue. A draft research protocol for fuel and fuel additives will be prepared.},
doi = {},
url = {https://www.osti.gov/biblio/5605971}, journal = {},
number = ,
volume = ,
place = {United States},
year = {},
month = {}
}

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