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Title: Radioiodinated ether phospholipid analogs as potential tumor-specific imaging agents

Abstract

Radioiodinated analogs of the naturally-occurring alkyl lysophospholipid (ALP) were designed and synthesized for evaluation as potential tumor-specific imaging agents. The five iodinated ALP analogs synthesized were rac-1-O-(12-(m-iodophenyl)dodecyl)glycero-3-phosphocholine, ET-12IP-OH; rac-1-O-(12-(m-iodophenyl)dodecyl)-2-O-methylglycero-3-phosphocholine, ET-12IP-OMe; rac-1-O-(12-(m-iodophenyl)dodecyl)propane-1,3-diol-3-phosphocholine, ET-12IP-H; rac-1-O-hexadecyl-2-O-(m-iodobenzoyl)-glycero-3-phosphocholine, ET-16-IBz and rac-1-O-hexadecyl-2-O-(m-iodobenzyl)-glycero-3-phosphocholine, ET-16-IBn. Four analogs, ET-12IP-OMe, ET-12IP-H, ET-16-IBz and ET-16-IBn were radiolabeled with iodine-125 in moderate yields via an isotope exchange procedure. ({sup 125}I)ET-12IP-OMe, ({sup 125}I)ET-12IP-H and ({sup 125}I)ET-16-IBz were evaluated in tissue distribution (TD) studies involving both normal and tumor-bearing rats. The tumor chosen for this study was the Walker 256 sarcoma which was implanted in the thigh. Based upon the TD results and the tumor to nontumor ratios, ({sup 125}I)-ET-12IP-OMe was selected for scintigraphic studies with rats bearing the Walker 256 sarcoma. Twenty-four hours following administration of the radiolabeled ALP analog, external imaging with a gamma-camera clearly delineated the tumor.

Authors:
Publication Date:
Research Org.:
Michigan Univ., Ann Arbor, MI (USA)
OSTI Identifier:
5605966
Resource Type:
Thesis/Dissertation
Resource Relation:
Other Information: Thesis (Ph. D.)
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; RADIOPHARMACEUTICALS; EVALUATION; SARCOMAS; DIAGNOSIS; EXPERIMENTAL NEOPLASMS; GAMMA CAMERAS; IODINE 125; RATS; SCINTISCANNING; TISSUE DISTRIBUTION; ANIMALS; BETA DECAY RADIOISOTOPES; CAMERAS; COUNTING TECHNIQUES; DAYS LIVING RADIOISOTOPES; DIAGNOSTIC TECHNIQUES; DISEASES; DISTRIBUTION; DRUGS; ELECTRON CAPTURE RADIOISOTOPES; INTERMEDIATE MASS NUCLEI; IODINE ISOTOPES; ISOTOPES; LABELLED COMPOUNDS; MAMMALS; NEOPLASMS; NUCLEI; ODD-EVEN NUCLEI; RADIOISOTOPE SCANNING; RADIOISOTOPES; RODENTS; VERTEBRATES; 550601* - Medicine- Unsealed Radionuclides in Diagnostics

Citation Formats

Meyer, K L. Radioiodinated ether phospholipid analogs as potential tumor-specific imaging agents. United States: N. p., 1988. Web.
Meyer, K L. Radioiodinated ether phospholipid analogs as potential tumor-specific imaging agents. United States.
Meyer, K L. 1988. "Radioiodinated ether phospholipid analogs as potential tumor-specific imaging agents". United States.
@article{osti_5605966,
title = {Radioiodinated ether phospholipid analogs as potential tumor-specific imaging agents},
author = {Meyer, K L},
abstractNote = {Radioiodinated analogs of the naturally-occurring alkyl lysophospholipid (ALP) were designed and synthesized for evaluation as potential tumor-specific imaging agents. The five iodinated ALP analogs synthesized were rac-1-O-(12-(m-iodophenyl)dodecyl)glycero-3-phosphocholine, ET-12IP-OH; rac-1-O-(12-(m-iodophenyl)dodecyl)-2-O-methylglycero-3-phosphocholine, ET-12IP-OMe; rac-1-O-(12-(m-iodophenyl)dodecyl)propane-1,3-diol-3-phosphocholine, ET-12IP-H; rac-1-O-hexadecyl-2-O-(m-iodobenzoyl)-glycero-3-phosphocholine, ET-16-IBz and rac-1-O-hexadecyl-2-O-(m-iodobenzyl)-glycero-3-phosphocholine, ET-16-IBn. Four analogs, ET-12IP-OMe, ET-12IP-H, ET-16-IBz and ET-16-IBn were radiolabeled with iodine-125 in moderate yields via an isotope exchange procedure. ({sup 125}I)ET-12IP-OMe, ({sup 125}I)ET-12IP-H and ({sup 125}I)ET-16-IBz were evaluated in tissue distribution (TD) studies involving both normal and tumor-bearing rats. The tumor chosen for this study was the Walker 256 sarcoma which was implanted in the thigh. Based upon the TD results and the tumor to nontumor ratios, ({sup 125}I)-ET-12IP-OMe was selected for scintigraphic studies with rats bearing the Walker 256 sarcoma. Twenty-four hours following administration of the radiolabeled ALP analog, external imaging with a gamma-camera clearly delineated the tumor.},
doi = {},
url = {https://www.osti.gov/biblio/5605966}, journal = {},
number = ,
volume = ,
place = {United States},
year = {Fri Jan 01 00:00:00 EST 1988},
month = {Fri Jan 01 00:00:00 EST 1988}
}

Thesis/Dissertation:
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