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Title: Synthetic crude oils carcinogenicity screening tests. Progress report, February 15-September 15, 1979

Abstract

Four crude oils (Southern Louisiana Crude Petroleum, H Coal Syncrude, Paraho Crude Shale Oil and Geokinetics in situ Shale Oil) which were distilled into four fractions (naphtha, mid-distillate, gas oil and residue) for analysis and biological screening testing during the first report period were tested for mutagenicity by the Ames test and for tumor initiating activity by an initiation/promotion (skin painting) test. Substantial agreement exists between Ames and skin painting results. Low boiling fractions of the 4 crude oils showed little or no mutagenicity or tumor activity by the two tests used. The higher boiling fractions (mid gas oils and residues) and the crude oils themselves showed positive mutagenicity and tumor initiation activity. The coal derived fractions were more potent by both tests while the shale oil fractions showed greater activity than the petroleum fractions but considerably less than the coal syncrude.

Authors:
; ; ; ;
Publication Date:
Research Org.:
Du Pont de Nemours (E.I.) and Co., Wilmington, DE (USA)
OSTI Identifier:
5603001
Report Number(s):
COO-4758-2
DOE Contract Number:  
EP-78-C-02-4758
Resource Type:
Technical Report
Country of Publication:
United States
Language:
English
Subject:
02 PETROLEUM; 63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; 04 OIL SHALES AND TAR SANDS; PETROLEUM; MUTAGEN SCREENING; PETROLEUM DISTILLATES; SHALE OIL; SYNTHETIC FUELS; CARCINOGENESIS; EXPERIMENTAL DATA; MICE; MUTAGENESIS; NAPHTHA; SKIN; TABLES; ANIMALS; BODY; COAL TAR OILS; DATA; DATA FORMS; DISTILLATES; ENERGY SOURCES; FOSSIL FUELS; FUELS; INFORMATION; MAMMALS; MINERAL OILS; NUMERICAL DATA; OILS; ORGANIC COMPOUNDS; ORGANS; OTHER ORGANIC COMPOUNDS; PATHOGENESIS; PETROLEUM FRACTIONS; RODENTS; SCREENING; SYNTHETIC PETROLEUM; VERTEBRATES; 020600* - Petroleum- Health & Safety; 560305 - Chemicals Metabolism & Toxicology- Vertebrates- (-1987); 040700 - Oil Shales & Tar Sands- Health & Safety

Citation Formats

Calkins, W H, Deye, J F, King, C F, Hartgrove, R W, and Krahn, D F. Synthetic crude oils carcinogenicity screening tests. Progress report, February 15-September 15, 1979. United States: N. p., 1979. Web. doi:10.2172/5603001.
Calkins, W H, Deye, J F, King, C F, Hartgrove, R W, & Krahn, D F. Synthetic crude oils carcinogenicity screening tests. Progress report, February 15-September 15, 1979. United States. https://doi.org/10.2172/5603001
Calkins, W H, Deye, J F, King, C F, Hartgrove, R W, and Krahn, D F. Mon . "Synthetic crude oils carcinogenicity screening tests. Progress report, February 15-September 15, 1979". United States. https://doi.org/10.2172/5603001. https://www.osti.gov/servlets/purl/5603001.
@article{osti_5603001,
title = {Synthetic crude oils carcinogenicity screening tests. Progress report, February 15-September 15, 1979},
author = {Calkins, W H and Deye, J F and King, C F and Hartgrove, R W and Krahn, D F},
abstractNote = {Four crude oils (Southern Louisiana Crude Petroleum, H Coal Syncrude, Paraho Crude Shale Oil and Geokinetics in situ Shale Oil) which were distilled into four fractions (naphtha, mid-distillate, gas oil and residue) for analysis and biological screening testing during the first report period were tested for mutagenicity by the Ames test and for tumor initiating activity by an initiation/promotion (skin painting) test. Substantial agreement exists between Ames and skin painting results. Low boiling fractions of the 4 crude oils showed little or no mutagenicity or tumor activity by the two tests used. The higher boiling fractions (mid gas oils and residues) and the crude oils themselves showed positive mutagenicity and tumor initiation activity. The coal derived fractions were more potent by both tests while the shale oil fractions showed greater activity than the petroleum fractions but considerably less than the coal syncrude.},
doi = {10.2172/5603001},
url = {https://www.osti.gov/biblio/5603001}, journal = {},
number = ,
volume = ,
place = {United States},
year = {1979},
month = {1}
}