Staging of carcinoma of the breast using a hand-held gamma detecting probe and monoclonal antibody B72. 3

Journal Article · Sat Jul 01 00:00:00 EDT 1989 · Surg. Gynecol. Obstet.; (United States)

OSTI ID:5601618

Nieroda, C A; Mojzisik, C; Sardi, A; Farrar, W B; Hinkle, G; Siddiqi, M A; Ferrara, P J; James, A; Schlom, J; Thurston, M O

Radioimmunoguided Surgery (RIGS) uses a hand-held gamma detecting probe to identify radiolabeled monoclonal antibodies (Mab). Fourteen patients with carcinoma of the breast proved at biopsy received Mab B72.3 (5 millicuries of /sup 125/I per 1 milligram, Iodo-Gen method) intravenously six to 26 days before exploration. Probe counts were measured intraoperatively in mammary tissue and axillary lymph nodes. In the mammary tissue, the RIGS system identified tumor that was histologically confirmed in seven of eight patients and confirmed the absence in four of six patients. Probe counts were suspicious for tumor that was not proved histologically in two of 14 patients. Unsuspected tumor was identified in three of 14 patients. In axillary tissue, probe counts identified one of two tumors that were confirmed histologically and verified the absence of tumor in eight of 12 patients. Probe counts in axillary tissue were suspicious for tumor that could not be documented histologically in four of 14 patients. RIGS appears to be able to identify residual, subclinical and multicentric carcinoma of the breast and accurately delineate the pattern of antigenic drainage of tumor into adjacent lymph nodes.

• Research Organization: Ohio State Univ. College of Medicine, Columbus (USA)
• OSTI ID: 5601618
• Journal Information: Surg. Gynecol. Obstet.; (United States), Vol. 169:1
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
CARCINOMAS
DIAGNOSIS
MAMMARY GLANDS
FEMALES
GAMMA RADIATION
IODINE 125
LYMPH NODES
METASTASES
MONOCLONAL ANTIBODIES
PATIENTS
SELF-POWERED GAMMA DETECTORS
ANTIBODIES
BETA DECAY RADIOISOTOPES
BODY
DAYS LIVING RADIOISOTOPES
DISEASES
ELECTROMAGNETIC RADIATION
ELECTRON CAPTURE RADIOISOTOPES
GLANDS
INTERMEDIATE MASS NUCLEI
IODINE ISOTOPES
IONIZING RADIATIONS
ISOTOPES
LYMPHATIC SYSTEM
MEASURING INSTRUMENTS
NEOPLASMS
NUCLEI
ODD-EVEN NUCLEI
ORGANS
RADIATION DETECTORS
RADIATIONS
RADIOISOTOPES
SELF-POWERED DETECTORS
550601* - Medicine- Unsealed Radionuclides in Diagnostics