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Title: Development and characterization of a continuous centrifugal bioreactor

Abstract

A new continuous centrifugal bioreactor (CCBR), has been developed and characterized. A densely packed fluidized bed was maintained by balancing the drag and buoyancy forces of the incoming substrate with that of the centrifugal forces. With this approach, effluent streams were relatively free of cells and a small residence time assured the provision of adequate nutrient requirements and rapid removal of the product. This concept was tested using a nonflocculating strain of the yeast Saccharomyces cerevisiae. The focus of this research was to clarify operating regimes and assess the feasibility of cell culture in a high gravity environment. (Refs. 14).

Authors:
; ; ;  [1]
  1. ed.
Publication Date:
Research Org.:
Washington State Univ., Pullman, WA 99164-2710, USA. Dept. Chemical Engineering
OSTI Identifier:
5593547
Report Number(s):
CONF-860508-
Journal ID: CODEN: BIBSB
Resource Type:
Conference
Journal Name:
Biotechnol. Bioeng. Symp.; (United States)
Additional Journal Information:
Journal Volume: 17; Conference: 8. symposium on biotechnology for fuels and chemicals, Gatlinburg, TN, USA, 13 May 1986
Country of Publication:
United States
Language:
English
Subject:
09 BIOMASS FUELS; BIOREACTORS; PERFORMANCE TESTING; FLUIDIZED BEDS; CELL CULTURES; DESIGN; SACCHAROMYCES CEREVISIAE; FUNGI; MICROORGANISMS; PLANTS; SACCHAROMYCES; TESTING; YEASTS; 140504* - Solar Energy Conversion- Biomass Production & Conversion- (-1989)

Citation Formats

Van Wie, B J, Elliott, M L, Lee, J M, and Scott, C D. Development and characterization of a continuous centrifugal bioreactor. United States: N. p., 1986. Web.
Van Wie, B J, Elliott, M L, Lee, J M, & Scott, C D. Development and characterization of a continuous centrifugal bioreactor. United States.
Van Wie, B J, Elliott, M L, Lee, J M, and Scott, C D. Wed . "Development and characterization of a continuous centrifugal bioreactor". United States.
@article{osti_5593547,
title = {Development and characterization of a continuous centrifugal bioreactor},
author = {Van Wie, B J and Elliott, M L and Lee, J M and Scott, C D},
abstractNote = {A new continuous centrifugal bioreactor (CCBR), has been developed and characterized. A densely packed fluidized bed was maintained by balancing the drag and buoyancy forces of the incoming substrate with that of the centrifugal forces. With this approach, effluent streams were relatively free of cells and a small residence time assured the provision of adequate nutrient requirements and rapid removal of the product. This concept was tested using a nonflocculating strain of the yeast Saccharomyces cerevisiae. The focus of this research was to clarify operating regimes and assess the feasibility of cell culture in a high gravity environment. (Refs. 14).},
doi = {},
journal = {Biotechnol. Bioeng. Symp.; (United States)},
number = ,
volume = 17,
place = {United States},
year = {1986},
month = {1}
}

Conference:
Other availability
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