Development and characterization of a continuous centrifugal bioreactor
Conference
·
· Biotechnol. Bioeng. Symp.; (United States)
OSTI ID:5593547
- ed.
A new continuous centrifugal bioreactor (CCBR), has been developed and characterized. A densely packed fluidized bed was maintained by balancing the drag and buoyancy forces of the incoming substrate with that of the centrifugal forces. With this approach, effluent streams were relatively free of cells and a small residence time assured the provision of adequate nutrient requirements and rapid removal of the product. This concept was tested using a nonflocculating strain of the yeast Saccharomyces cerevisiae. The focus of this research was to clarify operating regimes and assess the feasibility of cell culture in a high gravity environment. (Refs. 14).
- Research Organization:
- Washington State Univ., Pullman, WA 99164-2710, USA. Dept. Chemical Engineering
- OSTI ID:
- 5593547
- Report Number(s):
- CONF-860508-
- Journal Information:
- Biotechnol. Bioeng. Symp.; (United States), Journal Name: Biotechnol. Bioeng. Symp.; (United States) Vol. 17; ISSN BIBSB
- Country of Publication:
- United States
- Language:
- English
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