Influence of the location of left anterior descending coronary artery stenosis on left ventricular function during exercise

Journal Article · Fri Jan 01 00:00:00 EST 1982 · Circulation; (United States)

DOI:https://doi.org/10.1161/01.CIR.65.1.109· OSTI ID:5586613

Leong, K H; Jones, R H

The purpose of this investigation was to determine if a stenosis of a coronary artery located proximally caused greater deterioration of left ventricular function than a stenosis of a similar magnitude located more distally in the artery. Twenty-six patients with isolated left anterior descending coronary artery (LAD) lesions documented by cardiac catheterization were studied by radionuclide angiocardiography (RNA) at rest and during exercise on a bicycle ergometer. Thirteen patients (nine males and four females) had a proximal lesion of the LAD averaging 9.1 +/- 11% of the diameter of the lumen (group 1) and 13 patients (eight males and five females) had a distal lesion averaging 88 +/- 12% of the lumen (group 2). The mean age of group 1 was 49 +/- 9 years and the mean age of group 2 was 48 +/- 9 years. The findings indicate that a stenotic lesion located at a more proximal level of the coronary arterial system reduces blood flow in a larger area of myocardium, resulting in a more pronounced ischemic response to exercise than a similar lesion located more distally.

• Research Organization: Duke Univ., Durham, NC (United States). Medical Center
• OSTI ID: 5586613
• Journal Information: Circulation; (United States), Vol. 65:1
• Country of Publication: United States
• Language: English

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