Patterns of mutational sensitivity to chemicals in poststem-cell stages of mouse spermatogenesis

Conference · Sun Jan 01 00:00:00 EST 1989

OSTI ID:5584683

Russell, L B

For a given spermatozoon participating in conception, only a relatively short period of its cell lineage has been spent in poststem-cell stages of spermatogenesis. For this reason, the male genome participating in formation of the conceptus is less likely to have been exposed to mutagens during poststem-cell stages than during spermatogonial stem-cell of earlier stages. Nevertheless, in addressing questions of genetic hazard, the later stages cannot be ignored and may even represent a significant part of the risk if, as is already known for some mutagens, these cell types are disproportionally sensitive. Furthermore, the poststem-cell stages, which vary considerably amongst themselves in their array of chromosome and chromatin configurations, offer biological materials that are potentially useful in addressing questions of mutagenic mechanisms. 22 refs., 4 tabs.

• Research Organization: Oak Ridge National Lab., TN (USA)
• Sponsoring Organization: DOE/ER; DOHHS
• DOE Contract Number: AC05-84OR21400
• OSTI ID: 5584683
• Report Number(s): CONF-8907113-8; ON: DE89017762
• Resource Relation: Conference: 5. international conference on environmental mutagens, Cleveland, OH (USA), 10-15 Jul 1989
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
SPERMATOGENESIS
MUTATIONS
TOXIC MATERIALS
SENSITIVITY
DATA BASE MANAGEMENT
GENETIC EFFECTS
MICE
ANIMALS
BIOLOGICAL EFFECTS
GAMETOGENESIS
MAMMALS
MANAGEMENT
MATERIALS
RODENTS
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology