Studies on transposable elements in yeast. II. Deletions, duplications, and transpositions of the COR segment that encompasses the structural gene of yeast iso-1-cytochrome c
Rearrangements of chromosomal segments generally are rare events that appear to occur more or less randomly throughout the genomes of all organisms. However, consistent chromosomal alterations of specific segments are occasionally observed to occur at relatively high frequencies. Recently, researchers have found tha a specific chromosomal segment in certain but not all laboratory strains of Saccharomyces cerevisiae is deleted and transposed at high frequencies. This segment, denoted COR, encompasses the three closely linked loci CYC1, OSM1, and RAD7, which control iso-1-cytochrome c, osmotic sensitivity, and UV sensitivity, respectively. Two types of apparently normal laboratory strains of yeast, designated COR1 and COR2, were uncovered after the examination of the frequencies and types of mutations causing either deficiencies or overproduction of iso-10cytochrome c. In contrast to COR1 strains, which give predominantly point mutation causing deficiencies of iso-1-cytochrome c, COR2 strains give rise to deletions and transpositions of the COR segment. Researchers have undertaken a systematic investigation of the physical structure and genetic properties of the COR region and of the aberrations arising in COR2 strains.
- Research Organization:
- Univ. of Rochester, NY
- DOE Contract Number:
- AC02-76EV03490
- OSTI ID:
- 5580483
- Journal Information:
- Cold Spring Harbor Symp. Quant. Biol.; (United States), Vol. 45
- Country of Publication:
- United States
- Language:
- English
Similar Records
Genetic and biochemical analysis of the CYC7-H3 mutation that causes overproduction of yeast ISO-2-cytochrome C
An extensive deletion causing overproduction of yeast iso-2-cytochrome c
Related Subjects
GENE MUTATIONS
GENETIC EFFECTS
GENES
STRUCTURAL CHEMICAL ANALYSIS
SACCHAROMYCES CEREVISIAE
SENSITIVITY
CHEMICAL PROPERTIES
CHROMOSOMES
COMPARATIVE EVALUATIONS
CYTOCHROMES
BIOLOGICAL EFFECTS
FUNGI
MICROORGANISMS
MUTATIONS
PIGMENTS
PLANTS
SACCHAROMYCES
YEASTS
550400* - Genetics
550700 - Microbiology
550200 - Biochemistry