Relationship of thallium-201 myocardial perfusion pattern to regional and global left ventricular function with exercise
Thallium-201 redistribution pattern after exercise was related to rest and exercise left ventricular regional and global function, measured by radionuclide ventriculography, in 61 patients, 50 with coronary artery disease (CAD). Sixteen patients had exclusively transient thallium defects, suggesting ischemia: in this group, mean left ventricular ejection fraction (LVEF) was 65% at rest, falling to 58% during exercise (p less than 0.01). Eight patients had exclusively persistent thallium defects, suggesting scar: LVEF was unchanged during exercise, 58% to 59%. LVEF increased during exercise in the 17 patients without exercise thallium defects, seven with CAD: 66% to 73% (p less than 0.05). Individual LV wall segments which exhibited transient or persistent thallium defects contracted abnormally both at rest and during exercise; (2) both transient and persistent thallium defects can be associated with resting dyssynergy; and (3) in some CAD patients, apparent hypoperfusion does not necessarily predict left ventricular dysfunction during exercise.
- OSTI ID:
- 5578557
- Journal Information:
- Am. Heart J.; (United States), Vol. 101:6
- Country of Publication:
- United States
- Language:
- English
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63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
59 BASIC BIOLOGICAL SCIENCES
MYOCARDIUM
SCINTISCANNING
THALLIUM 201
DIAGNOSTIC USES
RADIONUCLIDE KINETICS
VASCULAR DISEASES
DIAGNOSIS
CORONARIES
EXERCISE
ISCHEMIA
PATIENTS
TISSUE DISTRIBUTION
ARTERIES
BETA DECAY RADIOISOTOPES
BLOOD VESSELS
BODY
CARDIOVASCULAR DISEASES
CARDIOVASCULAR SYSTEM
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DISEASES
DISTRIBUTION
ELECTRON CAPTURE RADIOISOTOPES
HEART
HEAVY NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MUSCLES
NUCLEI
ODD-EVEN NUCLEI
ORGANS
RADIOISOTOPE SCANNING
RADIOISOTOPES
SECONDS LIVING RADIOISOTOPES
THALLIUM ISOTOPES
USES
550601* - Medicine- Unsealed Radionuclides in Diagnostics
560171 - Radiation Effects- Nuclide Kinetics & Toxicology- Man- (-1987)
551001 - Physiological Systems- Tracer Techniques