Hypoxic radioprotection by temporary intestinal ischemia: degradable starch microsphere embolization in the cat
Temporary small intestinal ischemia was induced by mesenteric arteriolar embolization of degradable starch microspheres in cats. During ischemia, the small intestine received a surface dose of 7 Gy 200 kV x-ray irradiation. One group of animals also had received 7 Gy to the intact abdomen 72 hr earlier. The risk of thrombosis in small intestinal vessels during or after starch microsphere-induced ischemia combined with irradiation was evaluated by monitoring superior mesenteric arterial blood flow, by determination of blood platelets, fibrinogen, and factor VIII consumed across the mesenteric vascular bed, and by histologic examination of small intestinal vessels. Vascular integrity was inferred from intact response to isoproterenol and vasopressin after the combined trauma of ischemia and irradiation. No signs of thrombosis were detected in small intestinal vessels after temporary ischemia and irradiation. Hypoxic radioprotection of the small intestine in the cat can thus be achieved by mesenteric arterial microembolization of degradable starch spheres without evidence of thrombotic complications of significant vascular damage.
- Research Organization:
- Surgical Research Laboratory, University of Bergen, Norway
- OSTI ID:
- 5576219
- Journal Information:
- AJR, Am. J. Roentgenol.; (United States), Vol. 137:5
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
BLOOD FLOW
BIOLOGICAL RADIATION EFFECTS
BLOOD VESSELS
HISTOLOGY
SMALL INTESTINE
RADIATION PROTECTION
THROMBOSIS
RADIOINDUCTION
CATS
EMBOLI
ISCHEMIA
MICROSPHERES
STARCH
X RADIATION
ANIMALS
BIOLOGICAL EFFECTS
BODY
CARBOHYDRATES
CARDIOVASCULAR DISEASES
CARDIOVASCULAR SYSTEM
DIGESTIVE SYSTEM
DISEASES
ELECTROMAGNETIC RADIATION
GASTROINTESTINAL TRACT
INTESTINES
IONIZING RADIATIONS
MAMMALS
ORGANIC COMPOUNDS
ORGANS
POLYSACCHARIDES
RADIATION EFFECTS
RADIATIONS
REAGENTS
SACCHARIDES
VASCULAR DISEASES
VERTEBRATES
560152* - Radiation Effects on Animals- Animals