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Title: Antibody responses of mice exposed to low-power microwaves under combined, pulse-and-amplitude modulation

Abstract

Irradiation by pulsed microwaves (9.4 GHz, 1 microsecond pulses at 1,000/s), both with and without concurrent amplitude modulation (AM) by a sinusoid at discrete frequencies between 14 and 41 MHz, was assessed for effects on the immune system of Balb/C mice. The mice were immunized either by sheep red blood cells (SRBC) or by glutaric-anhydride conjugated bovine serum albumin (GA-BSA), then exposed to the microwaves at a low rms power density (30 microW/cm2; whole-body-averaged SAR approximately 0.015 W/kg). Sham exposure or microwave irradiation took place during each of five contiguous days, 10 h/day. The antibody response was evaluated by the plaque-forming cell assay (SRBC experiment) or by the titration of IgM and IgG antibodies (GA-BSA experiment). In the absence of AM, the pulsed field did not greatly alter immune responsiveness. In contrast, exposure to the field under the combined-modulation condition resulted in significant, AM-frequency-dependent augmentation or weakening of immune responses.

Authors:
; ; ; ; ; ; ; ;
Publication Date:
OSTI Identifier:
5573188
Resource Type:
Journal Article
Resource Relation:
Journal Name: Bioelectromagnetics (New York); (USA); Journal Volume: 12:1
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; MICROWAVE RADIATION; BIOLOGICAL EFFECTS; RETICULOENDOTHELIAL SYSTEM; SENSITIVITY; ALBUMINS; ANTIBODY FORMATION; IMMUNE REACTIONS; MICE; ANIMAL TISSUES; ANIMALS; BODY; ELECTROMAGNETIC RADIATION; MAMMALS; ORGANIC COMPOUNDS; PROTEINS; RADIATIONS; RODENTS; TISSUES; VERTEBRATES; 560400* - Other Environmental Pollutant Effects

Citation Formats

Veyret, B., Bouthet, C., Deschaux, P., de Seze, R., Geffard, M., Joussot-Dubien, J., le Diraison, M., Moreau, J.M., and Caristan, A.. Antibody responses of mice exposed to low-power microwaves under combined, pulse-and-amplitude modulation. United States: N. p., 1991. Web. doi:10.1002/bem.2250120107.
Veyret, B., Bouthet, C., Deschaux, P., de Seze, R., Geffard, M., Joussot-Dubien, J., le Diraison, M., Moreau, J.M., & Caristan, A.. Antibody responses of mice exposed to low-power microwaves under combined, pulse-and-amplitude modulation. United States. doi:10.1002/bem.2250120107.
Veyret, B., Bouthet, C., Deschaux, P., de Seze, R., Geffard, M., Joussot-Dubien, J., le Diraison, M., Moreau, J.M., and Caristan, A.. Tue . "Antibody responses of mice exposed to low-power microwaves under combined, pulse-and-amplitude modulation". United States. doi:10.1002/bem.2250120107.
@article{osti_5573188,
title = {Antibody responses of mice exposed to low-power microwaves under combined, pulse-and-amplitude modulation},
author = {Veyret, B. and Bouthet, C. and Deschaux, P. and de Seze, R. and Geffard, M. and Joussot-Dubien, J. and le Diraison, M. and Moreau, J.M. and Caristan, A.},
abstractNote = {Irradiation by pulsed microwaves (9.4 GHz, 1 microsecond pulses at 1,000/s), both with and without concurrent amplitude modulation (AM) by a sinusoid at discrete frequencies between 14 and 41 MHz, was assessed for effects on the immune system of Balb/C mice. The mice were immunized either by sheep red blood cells (SRBC) or by glutaric-anhydride conjugated bovine serum albumin (GA-BSA), then exposed to the microwaves at a low rms power density (30 microW/cm2; whole-body-averaged SAR approximately 0.015 W/kg). Sham exposure or microwave irradiation took place during each of five contiguous days, 10 h/day. The antibody response was evaluated by the plaque-forming cell assay (SRBC experiment) or by the titration of IgM and IgG antibodies (GA-BSA experiment). In the absence of AM, the pulsed field did not greatly alter immune responsiveness. In contrast, exposure to the field under the combined-modulation condition resulted in significant, AM-frequency-dependent augmentation or weakening of immune responses.},
doi = {10.1002/bem.2250120107},
journal = {Bioelectromagnetics (New York); (USA)},
number = ,
volume = 12:1,
place = {United States},
year = {Tue Jan 01 00:00:00 EST 1991},
month = {Tue Jan 01 00:00:00 EST 1991}
}