ECT imaging with Tc(V)-99m dimercaptosuccinic acid useful to detect lung metastases of osteosarcoma

Journal Article · Tue Jan 01 00:00:00 EST 1985 · Clin. Nucl. Med.; (United States)

DOI:https://doi.org/10.1097/00003072-198501000-00005· OSTI ID:5568446

Ohta, H; Ishii, M; Yoshizumi, M; Endo, K; Fujita, T; Nakajima, T; Sakahara, H; Torizuka, K; Kotoura, Y; Yokoyama, A

ECT imaging, using Tc(V)-99m dimercaptosuccinic acid (Tc(V)-DMS) was performed in two patients with lung metastasis of osteosarcoma, and the results were compared with those of CT scan. Clear accumulation of Tc(V)-DMS was recognized in all cases in the same area that CT scans demonstrated. Tc(V)-DMS was labeled under optimal pH 8, had very low SnCl/sub 2/ concentrations, an equilibrium between a stable form and a dissociated form of anion TcO/sub 4/(3-) structurally similar to PO/sub 4/(3-), and was postulated for tumor uptake. Considering this proposed mechanism for Tc(V)-DMS uptake by tumor cells, ECT imaging using this tracer could be of use in the early detection of lung metastasis of osteosarcoma.

• Research Organization: Kobe Tamatsu Hospital, Japan
• OSTI ID: 5568446
• Journal Information: Clin. Nucl. Med.; (United States), Vol. 10:1
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
LUNGS
COMPUTERIZED TOMOGRAPHY
OSTEOSARCOMAS
METASTASES
DIAGNOSIS
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LABELLED COMPOUNDS
PATIENTS
PH VALUE
SUCCINIC ACID
TECHNETIUM 99
TRACER TECHNIQUES
TUMOR CELLS
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BODY
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HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
NEOPLASMS
NUCLEI
ODD-EVEN NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
RADIOISOTOPES
RESPIRATORY SYSTEM
SARCOMAS
SKELETAL DISEASES
TECHNETIUM ISOTOPES
TOMOGRAPHY
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550601* - Medicine- Unsealed Radionuclides in Diagnostics