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Title: Analysis of cosmetic results following primary radiation therapy for stages I and II carcinoma of the breast. [4 MV linear accelerator; complications]

Abstract

In 31 cases of Stages I or II carcinoma of the breast treated by primary radiation therapy, the cosmetic results were analyzed with regard to the details of treatment. Three principal treatment factors were identified which influenced the cosmetic outcome: (1) the extent and location of the biopsy procedure; (2) the time/dose factors of the radiation therapy; and (3) the technique of the radiation therapy. Cosmetic results were lessened when the biopsy procedure included a wide resection of adjacent breast tissue or when the biopsy scar was obvious. Increasing doses of external beam radiation were associated with greater degrees of retraction and fibrosis of the treated breast. All 6 patients who received 6000 rad by external beam had significant retraction, and fibrosis while patients who received 5000 rad rarely showed significant changes. Local boost doses by interstitial implantation did not diminsh the cosmetic outcome. All patients were treated using supervoltage equipment without bolus and skin changes secondary to treatment were infrequent. Seventeen patients developed localized areas of fibrosis and skin changes at the matchline between adjacent radiation fields. Recommendations are made for improved cosmetic results based on these findings.

Authors:
; ; ;
Publication Date:
Research Org.:
Harvard Medical School, Boston, MA
OSTI Identifier:
5566970
Resource Type:
Journal Article
Journal Name:
Int. J. Radiat. Oncol., Biol. Phys.; (United States)
Additional Journal Information:
Journal Volume: 5:2
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; 62 RADIOLOGY AND NUCLEAR MEDICINE; ERYTHEMA; RADIOINDUCTION; FIBROSIS; MALFORMATIONS; MAMMARY GLANDS; BIOLOGICAL RADIATION EFFECTS; DEPTH DOSE DISTRIBUTIONS; RADIOTHERAPY; SIDE EFFECTS; SKIN; CARCINOMAS; CHEST; DOSE-RESPONSE RELATIONSHIPS; EXPERIMENTAL DATA; EXTERNAL IRRADIATION; FRACTIONATED IRRADIATION; ISOLATED VALUES; LINEAR ACCELERATORS; LOCAL IRRADIATION; PARTIAL BODY IRRADIATION; PATIENTS; TIME DEPENDENCE; ACCELERATORS; BIOLOGICAL EFFECTS; BODY; BODY AREAS; DATA; DATA FORMS; DISEASES; GLANDS; INFORMATION; IRRADIATION; MEDICINE; NEOPLASMS; NUCLEAR MEDICINE; NUMERICAL DATA; ORGANS; PATHOLOGICAL CHANGES; RADIATION DOSE DISTRIBUTIONS; RADIATION EFFECTS; RADIOLOGY; SPATIAL DOSE DISTRIBUTIONS; SYMPTOMS; THERAPY; 560151* - Radiation Effects on Animals- Man; 550603 - Medicine- External Radiation in Therapy- (1980-)

Citation Formats

Harris, J.R., Levene, M.B., Svensson, G., and Hellman, S. Analysis of cosmetic results following primary radiation therapy for stages I and II carcinoma of the breast. [4 MV linear accelerator; complications]. United States: N. p., 1979. Web. doi:10.1016/0360-3016(79)90729-6.
Harris, J.R., Levene, M.B., Svensson, G., & Hellman, S. Analysis of cosmetic results following primary radiation therapy for stages I and II carcinoma of the breast. [4 MV linear accelerator; complications]. United States. doi:10.1016/0360-3016(79)90729-6.
Harris, J.R., Levene, M.B., Svensson, G., and Hellman, S. Thu . "Analysis of cosmetic results following primary radiation therapy for stages I and II carcinoma of the breast. [4 MV linear accelerator; complications]". United States. doi:10.1016/0360-3016(79)90729-6.
@article{osti_5566970,
title = {Analysis of cosmetic results following primary radiation therapy for stages I and II carcinoma of the breast. [4 MV linear accelerator; complications]},
author = {Harris, J.R. and Levene, M.B. and Svensson, G. and Hellman, S.},
abstractNote = {In 31 cases of Stages I or II carcinoma of the breast treated by primary radiation therapy, the cosmetic results were analyzed with regard to the details of treatment. Three principal treatment factors were identified which influenced the cosmetic outcome: (1) the extent and location of the biopsy procedure; (2) the time/dose factors of the radiation therapy; and (3) the technique of the radiation therapy. Cosmetic results were lessened when the biopsy procedure included a wide resection of adjacent breast tissue or when the biopsy scar was obvious. Increasing doses of external beam radiation were associated with greater degrees of retraction and fibrosis of the treated breast. All 6 patients who received 6000 rad by external beam had significant retraction, and fibrosis while patients who received 5000 rad rarely showed significant changes. Local boost doses by interstitial implantation did not diminsh the cosmetic outcome. All patients were treated using supervoltage equipment without bolus and skin changes secondary to treatment were infrequent. Seventeen patients developed localized areas of fibrosis and skin changes at the matchline between adjacent radiation fields. Recommendations are made for improved cosmetic results based on these findings.},
doi = {10.1016/0360-3016(79)90729-6},
journal = {Int. J. Radiat. Oncol., Biol. Phys.; (United States)},
number = ,
volume = 5:2,
place = {United States},
year = {1979},
month = {2}
}