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Title: Effects of fractionated doses of fast neutrons and photons on the normal canine lung: relative biological effectiveness values obtained by radionuclide studies. [Exposures in therapeutic dose range (4000 to 6000 rad)]

Abstract

Thirty nine adult male beagles received either fast neutron or photon irradiation to the right thorax. There were 2 unirradiated control dogs. Twenty four dogs received fast neutrons with a mean energy of 15 MeV to total doses of 1000, 1500, 2250, or 3375 rad delivered in 4 fx/wk for 6 weeks. Fifteen dogs received total doses of 3000, 4500 or 6750 rad of photons (/sup 60/Co) in the same fractionation pattern. Radionuclide evaluations of pulmonary function were performed pre-irradiation and every three months post-irradiation for 1 year. These included: (1) radioaerosol deposition of an insoluble radiocolloid, /sup 99m/Tc-phytate; (2) /sup 133/Xe ventilation studies; and (3) /sup 99m/Tc-macroaggregated albumin perfusion images. Values for the relative biological effectiveness (RBE) of fast neutrons in producing changes in these parameters have been obtained by plotting the changes from pre-irradiation values in the right lung as function of the total dose. RBE values for the relative deposition of aerosol and the relative distribution of volume and perfusion have been obtained at 3, 6, 9 and 12 months post-irradiation. The relative biological effectiveness (RBE) for neutron damage to normal lung tissue was always greater than 4 in the clinical dose range of 4000 to 6000more » rad of photons.« less

Authors:
; ; ; ; ; ;
Publication Date:
Research Org.:
George Washington University, Washington, DC
OSTI Identifier:
5566737
Resource Type:
Journal Article
Journal Name:
Int. J. Radiat. Oncol., Biol. Phys.; (United States)
Additional Journal Information:
Journal Volume: 5:2
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; 62 RADIOLOGY AND NUCLEAR MEDICINE; 59 BASIC BIOLOGICAL SCIENCES; FAST NEUTRONS; RBE; LUNGS; DELAYED RADIATION EFFECTS; SCINTISCANNING; RESPIRATORY SYSTEM DISEASES; DIAGNOSIS; TECHNETIUM 99; XENON 133; ALBUMINS; BEAGLES; CHEST; COBALT 60; EXPERIMENTAL DATA; FRACTIONATED IRRADIATION; GAMMA RADIATION; ISOLATED VALUES; ISOMERIC NUCLEI; MEV RANGE 10-100; PARTIAL BODY IRRADIATION; PHYTIC ACID; RADIOPHARMACEUTICALS; ANIMALS; BARYONS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BIOLOGICAL EFFECTS; BIOLOGICAL RADIATION EFFECTS; BODY; BODY AREAS; COBALT ISOTOPES; COUNTING TECHNIQUES; DATA; DATA FORMS; DAYS LIVING RADIOISOTOPES; DIAGNOSTIC TECHNIQUES; DISEASES; DOGS; DRUGS; ELECTROMAGNETIC RADIATION; ELEMENTARY PARTICLES; ENERGY RANGE; ESTERS; EVEN-ODD NUCLEI; EXTERNAL IRRADIATION; FERMIONS; HADRONS; HOURS LIVING RADIOISOTOPES; INFORMATION; INTERMEDIATE MASS NUCLEI; INTERNAL CONVERSION RADIOISOTOPES; IONIZING RADIATIONS; IRRADIATION; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; LABELLED COMPOUNDS; LIPOTROPIC FACTORS; MAMMALS; MEV RANGE; MINUTES LIVING RADIOISOTOPES; NEUTRONS; NUCLEI; NUCLEONS; NUMERICAL DATA; ODD-EVEN NUCLEI; ODD-ODD NUCLEI; ORGANIC ACIDS; ORGANIC COMPOUNDS; ORGANIC PHOSPHORUS COMPOUNDS; ORGANS; PHOSPHORIC ACID ESTERS; PROTEINS; RADIATION EFFECTS; RADIATIONS; RADIOACTIVE MATERIALS; RADIOISOTOPE SCANNING; RADIOISOTOPES; RESPIRATORY SYSTEM; TECHNETIUM ISOTOPES; VERTEBRATES; XENON ISOTOPES; YEARS LIVING RADIOISOTOPES; 560152* - Radiation Effects on Animals- Animals; 550601 - Medicine- Unsealed Radionuclides in Diagnostics; 550900 - Pathology; 551000 - Physiological Systems; 550603 - Medicine- External Radiation in Therapy- (1980-)

Citation Formats

Bradley, E.W., Alderson, P.O., Deye, J.A., Mendenhall, K.G., Fisher, M.P., Vieras, F., and Rogers, C.C. Effects of fractionated doses of fast neutrons and photons on the normal canine lung: relative biological effectiveness values obtained by radionuclide studies. [Exposures in therapeutic dose range (4000 to 6000 rad)]. United States: N. p., 1979. Web. doi:10.1016/0360-3016(79)90720-X.
Bradley, E.W., Alderson, P.O., Deye, J.A., Mendenhall, K.G., Fisher, M.P., Vieras, F., & Rogers, C.C. Effects of fractionated doses of fast neutrons and photons on the normal canine lung: relative biological effectiveness values obtained by radionuclide studies. [Exposures in therapeutic dose range (4000 to 6000 rad)]. United States. doi:10.1016/0360-3016(79)90720-X.
Bradley, E.W., Alderson, P.O., Deye, J.A., Mendenhall, K.G., Fisher, M.P., Vieras, F., and Rogers, C.C. Thu . "Effects of fractionated doses of fast neutrons and photons on the normal canine lung: relative biological effectiveness values obtained by radionuclide studies. [Exposures in therapeutic dose range (4000 to 6000 rad)]". United States. doi:10.1016/0360-3016(79)90720-X.
@article{osti_5566737,
title = {Effects of fractionated doses of fast neutrons and photons on the normal canine lung: relative biological effectiveness values obtained by radionuclide studies. [Exposures in therapeutic dose range (4000 to 6000 rad)]},
author = {Bradley, E.W. and Alderson, P.O. and Deye, J.A. and Mendenhall, K.G. and Fisher, M.P. and Vieras, F. and Rogers, C.C.},
abstractNote = {Thirty nine adult male beagles received either fast neutron or photon irradiation to the right thorax. There were 2 unirradiated control dogs. Twenty four dogs received fast neutrons with a mean energy of 15 MeV to total doses of 1000, 1500, 2250, or 3375 rad delivered in 4 fx/wk for 6 weeks. Fifteen dogs received total doses of 3000, 4500 or 6750 rad of photons (/sup 60/Co) in the same fractionation pattern. Radionuclide evaluations of pulmonary function were performed pre-irradiation and every three months post-irradiation for 1 year. These included: (1) radioaerosol deposition of an insoluble radiocolloid, /sup 99m/Tc-phytate; (2) /sup 133/Xe ventilation studies; and (3) /sup 99m/Tc-macroaggregated albumin perfusion images. Values for the relative biological effectiveness (RBE) of fast neutrons in producing changes in these parameters have been obtained by plotting the changes from pre-irradiation values in the right lung as function of the total dose. RBE values for the relative deposition of aerosol and the relative distribution of volume and perfusion have been obtained at 3, 6, 9 and 12 months post-irradiation. The relative biological effectiveness (RBE) for neutron damage to normal lung tissue was always greater than 4 in the clinical dose range of 4000 to 6000 rad of photons.},
doi = {10.1016/0360-3016(79)90720-X},
journal = {Int. J. Radiat. Oncol., Biol. Phys.; (United States)},
number = ,
volume = 5:2,
place = {United States},
year = {1979},
month = {2}
}