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Title: Effects of. gamma. irradiation on plasma testosterone levels and hepatic drug metabolism in the rat. [Dimethylation of aminopyrine]

Abstract

When adult male Sprague-Dawley rats were exposed to whole-body irradiation of ..gamma.. rays ranging from 700 to 1000 rad, oxidative demethylation of drugs such as aminopyrine was significantly reduced. In agreement with the report of McTaggart and Wills, we have independently found that this irradiation-induced inhibition of hepatic drug metabolism was a result of blockage of testosterone synthesis or release. The plasma hormone levels in the treated animals (900 rad of ..gamma.. rays) declined gradually from a normal value of 5.5 +- 0.5 ng/ml to a minimum value of 0.9 +- 0.4 ng/ml, which was reached in 4 to 6 days after the irradiaton. It returned to normal level after the 10th day. This hormonal change caused by ..gamma.. irradiation was parallel with the change in aminopyrine demethylation, thus suggesting that impairment of hepatic drug metabolism by ..gamma.. rays was mainly secondary to the effect on the synthesis and/or release of the male sex hormone.

Authors:
; ;
Publication Date:
Research Org.:
Mahidol Univ., Bangkok, Thailand
OSTI Identifier:
5557467
Resource Type:
Journal Article
Journal Name:
Radiat. Res.; (United States)
Additional Journal Information:
Journal Volume: 19:1
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; ANALGESICS; METABOLISM; INHIBITION; TESTOSTERONE; BIOLOGICAL RADIATION EFFECTS; BIOSYNTHESIS; BLOOD PLASMA; COBALT 60; CORRELATIONS; GAMMA RADIATION; LIVER; RATS; SECRETION; WHOLE-BODY IRRADIATION; ANDROGENS; ANDROSTANES; ANIMALS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BIOLOGICAL EFFECTS; BIOLOGICAL MATERIALS; BLOOD; BODY; BODY FLUIDS; COBALT ISOTOPES; DIGESTIVE SYSTEM; DRUGS; ELECTROMAGNETIC RADIATION; EXTERNAL IRRADIATION; GLANDS; HORMONES; HYDROXY COMPOUNDS; INTERMEDIATE MASS NUCLEI; INTERNAL CONVERSION RADIOISOTOPES; IONIZING RADIATIONS; IRRADIATION; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; KETONES; MAMMALS; MATERIALS; MINUTES LIVING RADIOISOTOPES; NUCLEI; ODD-ODD NUCLEI; ORGANIC COMPOUNDS; ORGANS; RADIATION EFFECTS; RADIATIONS; RADIOISOTOPES; RODENTS; STEROID HORMONES; STEROIDS; SYNTHESIS; VERTEBRATES; YEARS LIVING RADIOISOTOPES; 560152* - Radiation Effects on Animals- Animals; 560114 - Radiation Effects on Biochemicals- In Animals- (-1987)

Citation Formats

Thithapandha, A, Chanachai, W, and Suriyachan, D. Effects of. gamma. irradiation on plasma testosterone levels and hepatic drug metabolism in the rat. [Dimethylation of aminopyrine]. United States: N. p., 1979. Web. doi:10.2307/3575033.
Thithapandha, A, Chanachai, W, & Suriyachan, D. Effects of. gamma. irradiation on plasma testosterone levels and hepatic drug metabolism in the rat. [Dimethylation of aminopyrine]. United States. https://doi.org/10.2307/3575033
Thithapandha, A, Chanachai, W, and Suriyachan, D. 1979. "Effects of. gamma. irradiation on plasma testosterone levels and hepatic drug metabolism in the rat. [Dimethylation of aminopyrine]". United States. https://doi.org/10.2307/3575033.
@article{osti_5557467,
title = {Effects of. gamma. irradiation on plasma testosterone levels and hepatic drug metabolism in the rat. [Dimethylation of aminopyrine]},
author = {Thithapandha, A and Chanachai, W and Suriyachan, D},
abstractNote = {When adult male Sprague-Dawley rats were exposed to whole-body irradiation of ..gamma.. rays ranging from 700 to 1000 rad, oxidative demethylation of drugs such as aminopyrine was significantly reduced. In agreement with the report of McTaggart and Wills, we have independently found that this irradiation-induced inhibition of hepatic drug metabolism was a result of blockage of testosterone synthesis or release. The plasma hormone levels in the treated animals (900 rad of ..gamma.. rays) declined gradually from a normal value of 5.5 +- 0.5 ng/ml to a minimum value of 0.9 +- 0.4 ng/ml, which was reached in 4 to 6 days after the irradiaton. It returned to normal level after the 10th day. This hormonal change caused by ..gamma.. irradiation was parallel with the change in aminopyrine demethylation, thus suggesting that impairment of hepatic drug metabolism by ..gamma.. rays was mainly secondary to the effect on the synthesis and/or release of the male sex hormone.},
doi = {10.2307/3575033},
url = {https://www.osti.gov/biblio/5557467}, journal = {Radiat. Res.; (United States)},
number = ,
volume = 19:1,
place = {United States},
year = {Sun Jul 01 00:00:00 EDT 1979},
month = {Sun Jul 01 00:00:00 EDT 1979}
}