Method for detecting and diagnosing disease caused by pathological protein aggregation
Patent Application
·
OSTI ID:555410
A method is provided for detecting pathological macromolecules in a patient, comprising obtaining body fluid from the patient, pretreating the body fluid, subjecting the pretreated body fluid to size-exclusion chromatography to create an excluded fluid, and analyzing the excluded fluid to detect macromolecules having a predetermined molecular weight. The method also allows for comparing elution spectra with reference spectra of suspect pathologic proteins.
- Research Organization:
- Argonne National Lab. (ANL), Argonne, IL (United States)
- Sponsoring Organization:
- USDOE Office of Energy Research, Washington, DC (United States)
- DOE Contract Number:
- W-31109-ENG-38
- Assignee:
- US Dept. of Energy, Washington, DC (United States)
- Patent Number(s):
- PATENTS-US-A8282473
- Application Number:
- ON: DE97009528; PAN: 8-282,473; TRN: AHC29802%%60
- OSTI ID:
- 555410
- Resource Relation:
- Other Information: PBD: 1994
- Country of Publication:
- United States
- Language:
- English
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