Markedly diminished epidermal keratinocyte expression of intercellular adhesion molecule-1 (ICAM-1) in Sezary syndrome

Journal Article · Fri Apr 21 00:00:00 EDT 1989 · JAMA, Journal of the American Medical Association; (USA)

DOI:https://doi.org/10.1001/jama.261.15.2217· OSTI ID:5547227

Nickoloff, B J; Griffiths, E M; Baadsgaard, O; Voorhees, J J; Hanson, C A; Cooper, K D ^[1]

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1. Univ. of Michigan Medical Center, Ann Arbor (USA)

In mucosis fungoides the malignant T cells express lymphocyte function-associated antigen-1, which allows them to bind to epidermal keratinocytes expressing the gamma interferon-inducible intercellular adhesion molecule-1. In this report, a patient with leukemic-stage mucosis fungoides (Sezary syndrome) had widespread erythematous dermal infiltrates containing malignant T cells, but without any epidermotropism. The authors discovered that the T cells expressed normal amounts of functional lymphocyte function-associated antigen-1, but the keratinocytes did not express significant levels of intercellular adhesion molecule-1, which was probably due to the inability of the malignant T cells to produce gamma interferon. These results support the concept that the inability of malignant T cells to enter the epidermis may contribute to emergence of more clinically aggressive T-cell clones that are no longer confined to the skin, but infiltrate the blood, lymph nodes, and viscera, as is seen in Sezary syndrome.

• OSTI ID: 5547227
• Journal Information: JAMA, Journal of the American Medical Association; (USA), Vol. 261:15; ISSN 0098-7484
• Country of Publication: United States
• Language: English

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59 BASIC BIOLOGICAL SCIENCES
DNA
HYBRIDIZATION
EPIDERMIS
CYTOCHEMISTRY
INTERFERON
RADIOIMMUNOASSAY
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ETIOLOGY
ANTIGENS
IODINE 125
LYMPHOCYTES
PATIENTS
PHOSPHORUS 32
RECEPTORS
TUMOR CELLS
ANIMAL CELLS
ANIMAL TISSUES
BETA DECAY RADIOISOTOPES
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BIOASSAY
BIOCHEMISTRY
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
CHEMISTRY
CONNECTIVE TISSUE CELLS
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DISEASES
ELECTRON CAPTURE RADIOISOTOPES
EPITHELIUM
GROWTH FACTORS
IMMUNOASSAY
IMMUNOLOGY
INTERMEDIATE MASS NUCLEI
IODINE ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
LEUKOCYTES
LIGHT NUCLEI
LYMPHOKINES
MATERIALS
MEMBRANE PROTEINS
MITOGENS
NUCLEI
NUCLEIC ACIDS
ODD-EVEN NUCLEI
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
ORGANS
PHOSPHORUS ISOTOPES
PROTEINS
RADIOASSAY
RADIOIMMUNODETECTION
RADIOIMMUNOLOGY
RADIOISOTOPES
SKIN
SOMATIC CELLS
TISSUES
TRACER TECHNIQUES
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