Cortical activation in profoundly deaf patients during cochlear implant stimulation demonstrated by H sub 2 (15)O PET

Journal Article · Wed May 01 00:00:00 EDT 1991 · Journal of Computer Assisted Tomography; (USA)

DOI:https://doi.org/10.1097/00004728-199105000-00005· OSTI ID:5545545

Herzog, H; Lamprecht, A; Kuehn, A R; Roden, W; Vosteen, K H; Feinendegen, L E ^[1]

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1. Institute of Medicine, Juelich, (West Germany)

Cochlear implants (CIs) are used to provide sensations of sound to profoundly deaf patients. The performance of the CI is assessed mainly by the subjective reports of patients. The aim of this study was to look for objective cortical responses to the stimulation of the CI. Two postlingually and two prelingually deaf patients were investigated by positron emission tomography (PET) using {sup 15}O-labeled water (H{sub 2}{sup 15}O) to determine the regional cerebral blood flow (rCBF). Instead of quantifying rCBF in absolute terms, it was estimated by referring the regional tissue concentration of H{sub 2}{sup 15}O to the mean whole brain concentration. CI stimulation encoded from white noise and sequential words led to an increased rCBF in the primary and secondary (Wernicke) auditory cortex. Relative elevations of up to 33% were observed bilaterally, although they were higher contralateral to the CI. These results were obtained not only in the postlingually deaf patients but also in two patients who had never been able to hear. Thus, it could be demonstrated that PET measurements of cerebral H{sub 2}{sup 15}O distribution yield objective responses of the central auditory system during electrical stimulation by CIs in profoundly deaf patients.

• OSTI ID: 5545545
• Journal Information: Journal of Computer Assisted Tomography; (USA), Vol. 15:3; ISSN 0363-8715
• Country of Publication: United States
• Language: English

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62 RADIOLOGY AND NUCLEAR MEDICINE
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OXYGEN 15
PATIENTS
POSITRON COMPUTED TOMOGRAPHY
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DIAGNOSTIC TECHNIQUES
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HYDROGEN COMPOUNDS
ISOTOPES
LIGHT NUCLEI
MINUTES LIVING RADIOISOTOPES
NERVOUS SYSTEM
NUCLEI
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OXYGEN ISOTOPES
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550601* - Medicine- Unsealed Radionuclides in Diagnostics