Blood lead levels after chronic feeding to mice of lead acetate with calcium phytate in the diet

Journal Article · Mon Nov 01 00:00:00 EST 1982 · Bull. Environ. Contam. Toxicol.; (United States)

DOI:https://doi.org/10.1007/BF01669619· OSTI ID:5532664

Wise, A

Female mice were fed diets containing either 0 or 20 g/kg calcium phytate with 0, 2, 10 or 50 mg/kg lead acetate. Animals were sacrificed at 3 or 6 months and blood samples were measured for lead by flameless atomic absorption spectrophotometry. There were no significant effects of either calcium phytate or lead acetate on body weight during the study. After 3 months feeding, the average weight was 35 g, and this increased slightly to 37 g after a further 3 months. After both 3 and 6 months feeding, there was no greater blood lead concentration in the 2 mg/kg group than in those given no lead acetate, although over the last 3 months both blood lead concentrations tripled. After feeding 10 mg/kg, a significant difference due to phytate appeared only in the 6 month group, however, at 50 mg/kg, there were significant effects of phytate after both 3 and 6 months feeding. (JMT)

• Research Organization: Medical Research Council Lab. Animals Centre, Surrey, England
• OSTI ID: 5532664
• Journal Information: Bull. Environ. Contam. Toxicol.; (United States), Vol. 29:5
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
LEAD
BIOLOGICAL EFFECTS
CHRONIC INTAKE
SPECTROPHOTOMETRY
BLOOD
INGESTION
MICE
RESPONSE MODIFYING FACTORS
TISSUE DISTRIBUTION
ANIMALS
BIOLOGICAL MATERIALS
BODY FLUIDS
DISTRIBUTION
ELEMENTS
INTAKE
MAMMALS
MATERIALS
METALS
RODENTS
VERTEBRATES
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)