Uptake and metabolism of indole compounds by the goldfish pineal organ
Indole metabolism was studied in the pineal organ of the goldfish by radioautography and high-performance liquid chromatography. The rate of uptake of tritiated serotonin was rapid in vitro with dense labeling over the photoreceptor cells. Tritiated tryptophan was taken up at a slower rate and the label was distributed evenly over the epithelium. Continual light caused a reduction in the concentration of serotonin (5-HT) and 5-hydroxyindoleacetic acid (5-HIAA) compared to groups exposed to constant darkness both in vivo and in explants, suggesting that these effects are not derived from photoreceptors outside the pineal organ. These data are consistent with the hypothesis that indole metabolism is functionally linked to phototransduction events in the pineal organ of lower vertebrates.
- Research Organization:
- Loyola Univ. Medical Center, Maywood, IL
- OSTI ID:
- 5531375
- Journal Information:
- Gen. Comp. Endocrinol.; (United States), Vol. 2
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
INDOLES
METABOLISM
UPTAKE
PINEAL GLAND
AUTORADIOGRAPHY
PHOTOSENSITIVITY
BIOLOGICAL LOCALIZATION
GOLDFISH
SEROTONIN
TRYPTOPHAN
AMINES
AMINO ACIDS
ANIMALS
AQUATIC ORGANISMS
AROMATICS
AUTONOMIC NERVOUS SYSTEM AGENTS
AZAARENES
AZOLES
BODY
CARBOXYLIC ACIDS
DRUGS
FISHES
GLANDS
HETEROCYCLIC ACIDS
HETEROCYCLIC COMPOUNDS
HYDROXY COMPOUNDS
NEUROREGULATORS
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PYRROLES
RADIOPROTECTIVE SUBSTANCES
SENSITIVITY
SYMPATHOMIMETICS
TRYPTAMINES
VERTEBRATES
550501* - Metabolism- Tracer Techniques