Neovascular glaucoma after helium ion irradiation for uveal melanoma
Neovascular glaucoma developed in 22 of 169 uveal melanoma patients treated with helium ion irradiation. Most patients had large melanomas; no eyes containing small melanomas developed anterior segment neovascularization. The mean onset of glaucoma was 14.1 months (range, 7-31 months). The incidence of anterior segment neovascularization increased with radiation dosage; there was an approximately three-fold increase at 80 GyE versus 60 GyE of helium ion radiation (23% vs. 8.5%) (P less than 0.05). Neovascular glaucoma occurred more commonly in larger tumors; the incidence was not affected by tumor location, presence of subretinal fluid, nor rate of tumor regression. Fifty-three percent of patients had some response with intraocular pressures of 21 mmHg or less to a combination of antiglaucoma treatments.
- Research Organization:
- Univ. of California, San Francisco
- OSTI ID:
- 5528569
- Journal Information:
- Ophthalmology (Rochester, Minn.); (United States), Vol. 2
- Country of Publication:
- United States
- Language:
- English
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62 RADIOLOGY AND NUCLEAR MEDICINE
EYES
BIOLOGICAL RADIATION EFFECTS
RADIOTHERAPY
SIDE EFFECTS
HELIUM IONS
MELANOMAS
PATIENTS
SENSE ORGANS DISEASES
BIOLOGICAL EFFECTS
BODY
BODY AREAS
CHARGED PARTICLES
DISEASES
FACE
HEAD
IONS
MEDICINE
NEOPLASMS
NUCLEAR MEDICINE
ORGANS
RADIATION EFFECTS
RADIOLOGY
SENSE ORGANS
THERAPY
560151* - Radiation Effects on Animals- Man
550603 - Medicine- External Radiation in Therapy- (1980-)