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Title: The carcinogenic effect of aromatic amines: an epidemiological study on the role of o-toluidine and 4,4'-methylene bis (2-methylaniline) in inducing bladder cancer in man

Abstract

Cause-specific mortality of 906 workers first employed 1922-1970 in a dyestuff factory in Northern Italy was compared to national figures: a marked excess of bladder cancer was observed (36 observed vs 1.23 expected deaths). The mean latent period was 25 years. The excess was higher among those with longer duration of exposure. Some excess of mortality from lung cancer, laryngeal cancer, and esophageal cancer was also found, but a clear explanation could not be provided regarding the causal role of aromatic amines. Mortality from bladder cancer was very much higher among those exposed in benzidine and naphthylamines manufacture as compared to those only exposed in use or intermittent contact. Excess bladder cancer was also very high among workers in fuchsin manufacture. There is evidence that o-toluidine and 4,4'-methylene bis(2-methylaniline) should be implicated in such excess mortality. Caution in handling these compounds is therefore suggested and the need for further studies to confirm such findings is stressed.

Authors:
; ; ;
Publication Date:
Research Org.:
Turin Univ., Torino, Italy
OSTI Identifier:
5527995
Resource Type:
Journal Article
Journal Name:
Environ. Res.; (United States)
Additional Journal Information:
Journal Volume: 27:2
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; AMINES; BIOLOGICAL EFFECTS; CARCINOGENESIS; BLADDER; ONCOGENIC TRANSFORMATIONS; DYES; EPIDEMIOLOGY; LATENCY PERIOD; MANUFACTURING; MORTALITY; NEOPLASMS; PERSONNEL; BODY; DISEASES; ORGANIC COMPOUNDS; ORGANS; PATHOGENESIS; URINARY TRACT; 560306* - Chemicals Metabolism & Toxicology- Man- (-1987)

Citation Formats

Rubino, G F, Scansetti, G, Piolatto, G, and Pira, E. The carcinogenic effect of aromatic amines: an epidemiological study on the role of o-toluidine and 4,4'-methylene bis (2-methylaniline) in inducing bladder cancer in man. United States: N. p., 1982. Web. doi:10.1016/0013-9351(82)90079-2.
Rubino, G F, Scansetti, G, Piolatto, G, & Pira, E. The carcinogenic effect of aromatic amines: an epidemiological study on the role of o-toluidine and 4,4'-methylene bis (2-methylaniline) in inducing bladder cancer in man. United States. https://doi.org/10.1016/0013-9351(82)90079-2
Rubino, G F, Scansetti, G, Piolatto, G, and Pira, E. 1982. "The carcinogenic effect of aromatic amines: an epidemiological study on the role of o-toluidine and 4,4'-methylene bis (2-methylaniline) in inducing bladder cancer in man". United States. https://doi.org/10.1016/0013-9351(82)90079-2.
@article{osti_5527995,
title = {The carcinogenic effect of aromatic amines: an epidemiological study on the role of o-toluidine and 4,4'-methylene bis (2-methylaniline) in inducing bladder cancer in man},
author = {Rubino, G F and Scansetti, G and Piolatto, G and Pira, E},
abstractNote = {Cause-specific mortality of 906 workers first employed 1922-1970 in a dyestuff factory in Northern Italy was compared to national figures: a marked excess of bladder cancer was observed (36 observed vs 1.23 expected deaths). The mean latent period was 25 years. The excess was higher among those with longer duration of exposure. Some excess of mortality from lung cancer, laryngeal cancer, and esophageal cancer was also found, but a clear explanation could not be provided regarding the causal role of aromatic amines. Mortality from bladder cancer was very much higher among those exposed in benzidine and naphthylamines manufacture as compared to those only exposed in use or intermittent contact. Excess bladder cancer was also very high among workers in fuchsin manufacture. There is evidence that o-toluidine and 4,4'-methylene bis(2-methylaniline) should be implicated in such excess mortality. Caution in handling these compounds is therefore suggested and the need for further studies to confirm such findings is stressed.},
doi = {10.1016/0013-9351(82)90079-2},
url = {https://www.osti.gov/biblio/5527995}, journal = {Environ. Res.; (United States)},
number = ,
volume = 27:2,
place = {United States},
year = {Thu Apr 01 00:00:00 EST 1982},
month = {Thu Apr 01 00:00:00 EST 1982}
}