Radiohalogenated thienylethylamine derivatives for evaluating local cerebral blood flow
Patent Application
·
OSTI ID:5516699
An improved method of chemical synthesis of radiohalogenated thienylethylamine derivatives useful in brain imaging is described. These 5-halo-thiophene-2-isopropyl amines readily cross the blood- brain barrier and are retained in the brain for a sufficient length of time to allow evaluation of regional blood flow in the cerebrum. The advantages of the invention include a simpler synthesis route and a final compound which is less diluted with nonradioactive halogen. Use of this invention will allow clearer radioimaging or lower radiation doses to the patient, depending on the objective. 2 figs., 1 tab. (MHB)
- Research Organization:
- Oak Ridge National Lab., TN (United States)
- Sponsoring Organization:
- USDOE; USDOE, Washington, DC (United States)
- DOE Contract Number:
- AC05-84OR21400
- Assignee:
- Department of Energy
- Patent Number(s):
- PATENTS-US-A7288349
- Application Number:
- ON: DE91016860; PPN: US 7-288349
- OSTI ID:
- 5516699
- Country of Publication:
- United States
- Language:
- English
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Radiohalogenated thienylethylamine derivatives for evaluating local cerebral blood flow
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Tue Feb 13 00:00:00 EST 1990
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Related Subjects
38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY
62 RADIOLOGY AND NUCLEAR MEDICINE
59 BASIC BIOLOGICAL SCIENCES
AMINES
IODINATION
ISOTOPIC EXCHANGE
CEREBRUM
BLOOD FLOW
RADIOPHARMACEUTICALS
CHEMICAL PREPARATION
TISSUE DISTRIBUTION
BLOOD-BRAIN BARRIER
BROMINE 75
BROMINE 82
CHEMICAL REACTIONS
DIAGNOSTIC USES
INVENTIONS
IODINE 122
IODINE 123
IODINE 125
NUCLEAR MEDICINE
PATENTS
SCINTISCANNING
SPECIFICATIONS
TRACER TECHNIQUES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BODY
BRAIN
BROMINE ISOTOPES
CENTRAL NERVOUS SYSTEM
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DISTRIBUTION
DOCUMENT TYPES
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
HALOGENATION
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
IODINE ISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
LABELLED COMPOUNDS
MEDICINE
MICROSEC LIVING RADIOISOTOPES
MINUTES LIVING RADIOISOTOPES
NERVOUS SYSTEM
NUCLEI
ODD-EVEN NUCLEI
ODD-ODD NU
ODD-ODD NUC
ORGANIC COMPOUNDS
ORGANS
RADIOISOTOPE SCANNING
RADIOISOTOPES
SYNTHESIS
USES
400703* - Radiochemistry & Nuclear Chemistry- Radioisotope Production
550601 - Medicine- Unsealed Radionuclides in Diagnostics
551001 - Physiological Systems- Tracer Techniques
62 RADIOLOGY AND NUCLEAR MEDICINE
59 BASIC BIOLOGICAL SCIENCES
AMINES
IODINATION
ISOTOPIC EXCHANGE
CEREBRUM
BLOOD FLOW
RADIOPHARMACEUTICALS
CHEMICAL PREPARATION
TISSUE DISTRIBUTION
BLOOD-BRAIN BARRIER
BROMINE 75
BROMINE 82
CHEMICAL REACTIONS
DIAGNOSTIC USES
INVENTIONS
IODINE 122
IODINE 123
IODINE 125
NUCLEAR MEDICINE
PATENTS
SCINTISCANNING
SPECIFICATIONS
TRACER TECHNIQUES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BODY
BRAIN
BROMINE ISOTOPES
CENTRAL NERVOUS SYSTEM
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DISTRIBUTION
DOCUMENT TYPES
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
HALOGENATION
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
IODINE ISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
LABELLED COMPOUNDS
MEDICINE
MICROSEC LIVING RADIOISOTOPES
MINUTES LIVING RADIOISOTOPES
NERVOUS SYSTEM
NUCLEI
ODD-EVEN NUCLEI
ODD-ODD NU
ODD-ODD NUC
ORGANIC COMPOUNDS
ORGANS
RADIOISOTOPE SCANNING
RADIOISOTOPES
SYNTHESIS
USES
400703* - Radiochemistry & Nuclear Chemistry- Radioisotope Production
550601 - Medicine- Unsealed Radionuclides in Diagnostics
551001 - Physiological Systems- Tracer Techniques