Ultraviolet mutagenesis and the SOS response in Escherichia coli: A personal perspective

Journal Article · Sun Jan 01 00:00:00 EST 1989 · Environmental and Molecular Mutagenesis; (USA)

DOI:https://doi.org/10.1002/em.2850140608· OSTI ID:5513701

Witkin, E M ^[1]

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1. Rutgers, State Univ. of New Jersey, Piscataway (USA)

The study of ultraviolet (UV) mutagenesis in Escherichia coli began with the assumption that genes were likely to be changed at the instant of photon absorption. Over many decades, it became clear that postirradiation cellular activities, including enzymatic DNA repair of UV photo products and error-prone modes of tolerating unrepaired DNA lesions can exert profound influences on the mutagenic outcome of irradiation. Current study focusses on the molecular details of radiation-induced translesion DNA replication as the final event in UV mutagenesis.

• OSTI ID: 5513701
• Journal Information: Environmental and Molecular Mutagenesis; (USA), Journal Name: Environmental and Molecular Mutagenesis; (USA); ISSN 0893-6692
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ESCHERICHIA COLI
DNA REPAIR
MUTATIONS
RADIOINDUCTION
ULTRAVIOLET RADIATION
MUTAGENESIS
GENETIC RADIATION EFFECTS
HISTORICAL ASPECTS
MUTAGEN SCREENING
MUTAGENS
BACTERIA
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BIOLOGICAL RECOVERY
BIOLOGICAL REPAIR
ELECTROMAGNETIC RADIATION
GENETIC EFFECTS
MICROORGANISMS
RADIATION EFFECTS
RADIATIONS
RECOVERY
REPAIR
SCREENING
560130* - Radiation Effects on Microorganisms