Synthesis of unsymmetric disulfides as potential antiradiation drugs

Womble, S W

Title: Synthesis of unsymmetric disulfides as potential antiradiation drugs

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Abstract

This research involved the synthesis of unsymmetric disulfides which contain the radioprotective compound cysteamine attached to a biologically active molecule via a disulfide linkage. This study involved the synthesis of unsymmetric disulfides of cysteamine with amino acids, amino acid esters, steroidal thiols, glutathione, and other known radio-protective compounds which were submitted for biological evaluation. It is hoped that by attaching a known radioprotective compound to a molecule such as an amino acid or steroid we may obtain an enhanced concentration of the radioprotective substance in the target areas within the cell. The use of steroidal thiols coupled to cysteamine may result in the protection of the central nervous system for which there is no known radioprotective agent available. In the second part of this work a synthesis of a thiol containing polymer was developed which would give a highly functionalized product. This thiol containing polymer can be utilized in a solid phase synthesis scheme for the preparation of unsymmetric disulfides free of side products.

Authors:: Womble, S W

Publication Date:: Fri Jan 01 00:00:00 EST 1988

Research Org.:: Texas Univ., Arlington, TX (USA)

OSTI Identifier:: 5512748

Resource Type:: Thesis/Dissertation

Resource Relation:: Other Information: Thesis (Ph. D.)

Country of Publication:: United States

Language:: English

Subject:: 63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; DISULFIDES; RADIOSENSITIVITY EFFECTS; RADIOPROTECTIVE SUBSTANCES; CHEMICAL PREPARATION; IONIZING RADIATIONS; DRUGS; ORGANIC COMPOUNDS; ORGANIC SULFUR COMPOUNDS; RADIATIONS; SYNTHESIS; 560151* - Radiation Effects on Animals- Man

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                    Womble, S W. Synthesis of unsymmetric disulfides as potential antiradiation drugs.  United States: N. p., 1988. 
        Web.

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                    Womble, S W. Synthesis of unsymmetric disulfides as potential antiradiation drugs.  United States.

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                    Womble, S W. 1988.  
        "Synthesis of unsymmetric disulfides as potential antiradiation drugs".  United States.

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@article{osti_5512748,

  title        = {Synthesis of unsymmetric disulfides as potential antiradiation drugs},

  author       = {Womble, S W},

  abstractNote = {This research involved the synthesis of unsymmetric disulfides which contain the radioprotective compound cysteamine attached to a biologically active molecule via a disulfide linkage. This study involved the synthesis of unsymmetric disulfides of cysteamine with amino acids, amino acid esters, steroidal thiols, glutathione, and other known radio-protective compounds which were submitted for biological evaluation. It is hoped that by attaching a known radioprotective compound to a molecule such as an amino acid or steroid we may obtain an enhanced concentration of the radioprotective substance in the target areas within the cell. The use of steroidal thiols coupled to cysteamine may result in the protection of the central nervous system for which there is no known radioprotective agent available. In the second part of this work a synthesis of a thiol containing polymer was developed which would give a highly functionalized product. This thiol containing polymer can be utilized in a solid phase synthesis scheme for the preparation of unsymmetric disulfides free of side products.},

  doi          = {},

  url          = {https://www.osti.gov/biblio/5512748},
  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {Fri Jan 01 00:00:00 EST 1988},

  month        = {Fri Jan 01 00:00:00 EST 1988}

}

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