Human fibroblast strain with normal survival but abnormal postreplication repair after ultraviolet light irradiation

Journal Article · Fri Aug 01 00:00:00 EDT 1980 · Cancer Res.; (United States)

OSTI ID:5512211

Doniger, J; Barrett, S F; Robbins, J H

Postreplication repair has been studied in ultraviolet light (UV-irradiated) fibroblast strains derived from eight apparently normal control donors and seven xeroderma pigmentosum patients. One control donor strain had an intermediate defect in postreplication repair similar to that in excision-deficient xeroderma pigmentosum fibroblasts. However, unlike the xeroderma pigmentosum strains, this control donor strain had normal UV-induced unscheduled DNA synthesis and normal survival after irradiation with UV. This unique fibroblast strain should be useful in studies designed to elucidate the possible role of postreplication repair in UV-induced carcinogenesis and mutagenesis.

• Research Organization: National Cancer Inst., Bethesda, MD
• OSTI ID: 5512211
• Journal Information: Cancer Res.; (United States), Vol. 40:8
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
FIBROBLASTS
RADIOSENSITIVITY EFFECTS
RADIATION INJURIES
BIOLOGICAL REPAIR
ULTRAVIOLET RADIATION
BIOLOGICAL RADIATION EFFECTS
ANIMAL CELLS
DNA
DNA REPLICATION
EXTERNAL IRRADIATION
PATIENTS
XERODERMA PIGMENTOSUM
BIOLOGICAL EFFECTS
BIOLOGICAL RECOVERY
CONNECTIVE TISSUE CELLS
DISEASES
ELECTROMAGNETIC RADIATION
INJURIES
IRRADIATION
NUCLEIC ACID REPLICATION
NUCLEIC ACIDS
ORGANIC COMPOUNDS
RADIATION EFFECTS
RADIATIONS
RECOVERY
REPAIR
SKIN DISEASES
SOMATIC CELLS
560121* - Radiation Effects on Cells- External Source- (-1987)