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Title: History of the use and toxicity of Thorotrast

Abstract

The history of Thorotrast use is given beginning with the drug's introduction as a contrast media in 1931, through its widespread use in the 1930's, and the discontinuence of its use in the 1940's due to the realization of possible long-term side effects. Common among these side effects are local granulomas at administration site; tumors of the rectum, colon, stomach, esophagus, larynx, uterus, fallopian tubes, bladder, breasts, bile duct, and brain; the appearance of hemangioendotheliomata in the liver, spleen, and bone marrow 25 to 30 years after Thorotrast administration; and blood dyscrasias appearing characteristically 17 years after Thorotrast administration. (DP)

Authors:
Publication Date:
Research Org.:
Laboratory Centre for Disease Control, Ottawa, Ontario
OSTI Identifier:
5511484
Resource Type:
Journal Article
Journal Name:
Environ. Res.; (United States)
Additional Journal Information:
Journal Volume: 18:1
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; 62 RADIOLOGY AND NUCLEAR MEDICINE; BILIARY TRACT; DELAYED RADIATION EFFECTS; BLADDER; BLOOD PLASMA; RADIOINDUCTION; BONE MARROW; BRAIN; DIAGNOSTIC TECHNIQUES; SIDE EFFECTS; ESOPHAGUS; GRANULOMAS; HEMIC DISEASES; LARGE INTESTINE; LARYNX; LIVER; MAMMARY GLANDS; NEOPLASMS; RECTUM; SPLEEN; STOMACH; THOROTRAST; CARCINOGENESIS; TOXICITY; LATENCY PERIOD; MEDICAL SURVEILLANCE; PATIENTS; RADIONUCLIDE ADMINISTRATION; UTERUS; ACTINIDE COMPOUNDS; BIOLOGICAL EFFECTS; BIOLOGICAL MATERIALS; BIOLOGICAL RADIATION EFFECTS; BLOOD; BODY; BODY FLUIDS; CENTRAL NERVOUS SYSTEM; CHALCOGENIDES; COLLOIDS; CONTRAST MEDIA; DIGESTIVE SYSTEM; DISEASES; DISPERSIONS; FEMALE GENITALS; GASTROINTESTINAL TRACT; GLANDS; HEMATOPOIETIC SYSTEM; INTESTINES; MATERIALS; NERVOUS SYSTEM; ORGANS; OXIDES; OXYGEN COMPOUNDS; PATHOGENESIS; PATHOLOGICAL CHANGES; RADIATION EFFECTS; RADIOCOLLOIDS; RESPIRATORY SYSTEM; THORIUM COMPOUNDS; THORIUM OXIDES; TISSUES; URINARY TRACT; 560161* - Radionuclide Effects, Kinetics, & Toxicology- Man; 550602 - Medicine- External Radiation in Diagnostics- (1980-)

Citation Formats

Abbatt, J.D. History of the use and toxicity of Thorotrast. United States: N. p., 1979. Web. doi:10.1016/0013-9351(79)90131-2.
Abbatt, J.D. History of the use and toxicity of Thorotrast. United States. doi:10.1016/0013-9351(79)90131-2.
Abbatt, J.D. Thu . "History of the use and toxicity of Thorotrast". United States. doi:10.1016/0013-9351(79)90131-2.
@article{osti_5511484,
title = {History of the use and toxicity of Thorotrast},
author = {Abbatt, J.D.},
abstractNote = {The history of Thorotrast use is given beginning with the drug's introduction as a contrast media in 1931, through its widespread use in the 1930's, and the discontinuence of its use in the 1940's due to the realization of possible long-term side effects. Common among these side effects are local granulomas at administration site; tumors of the rectum, colon, stomach, esophagus, larynx, uterus, fallopian tubes, bladder, breasts, bile duct, and brain; the appearance of hemangioendotheliomata in the liver, spleen, and bone marrow 25 to 30 years after Thorotrast administration; and blood dyscrasias appearing characteristically 17 years after Thorotrast administration. (DP)},
doi = {10.1016/0013-9351(79)90131-2},
journal = {Environ. Res.; (United States)},
number = ,
volume = 18:1,
place = {United States},
year = {1979},
month = {2}
}