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Title: Microdistribution of Thorotrast conglomerates in lymph nodes and radiation exposure of single lymphocytes

Abstract

In Thorotrast patients, chromosome aberrations of lymphocytes from peripheral blood are to be used as a biological dosimeter. To get a significant dose-effect relationship it is necessary to estimate the absorbed dose of a single lymphocyte during its exposure time. In individual cases only average values can be calculated, based on assumptions of special distributions of Thorotrast. At first effects of the size of Thorotrast conglomerates and of their space distribution on the ..cap alpha..-radiation dose distribution in their surroundings are described in a model. Then this model is transferred to the real dimensions and the histological structures of lymph nodes bearing Thorotrast. In some individual cases the microdistribution of Thorotrast has been determined in lymph nodes. Some of these results are demonstrated. According to these Thorotrast distributions, calculation of real absorbed dose of lymphocytes are performed. These values can be used for setting up a dose-effect relationship for biological dosimetry.

Authors:
; ;
Publication Date:
Research Org.:
Universitaet des Saarlandes, Homburg, Germany
OSTI Identifier:
5511352
Resource Type:
Journal Article
Journal Name:
Environ. Res.; (United States)
Additional Journal Information:
Journal Volume: 18:1
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; 62 RADIOLOGY AND NUCLEAR MEDICINE; CHROMOSOMAL ABERRATIONS; RADIOINDUCTION; HAMSTERS; BIOLOGICAL RADIATION EFFECTS; LYMPH NODES; LYMPHOCYTES; PATIENTS; THOROTRAST; RADIONUCLIDE KINETICS; AGGLOMERATION; BIOLOGICAL INDICATORS; BIOLOGICAL MODELS; DOSE RATES; DOSE-RESPONSE RELATIONSHIPS; EXPERIMENTAL DATA; ISOLATED VALUES; RADIATION DOSE DISTRIBUTIONS; ACTINIDE COMPOUNDS; ANIMAL CELLS; ANIMALS; BIOLOGICAL EFFECTS; BIOLOGICAL MATERIALS; BLOOD; BLOOD CELLS; BODY FLUIDS; CHALCOGENIDES; COLLOIDS; CONNECTIVE TISSUE CELLS; CONTRAST MEDIA; DATA; DATA FORMS; DISPERSIONS; INFORMATION; LEUKOCYTES; LYMPHATIC SYSTEM; MAMMALS; MATERIALS; MUTATIONS; NUMERICAL DATA; OXIDES; OXYGEN COMPOUNDS; RADIATION EFFECTS; RADIOCOLLOIDS; RODENTS; SOMATIC CELLS; THORIUM COMPOUNDS; THORIUM OXIDES; VERTEBRATES; 560171* - Radiation Effects- Nuclide Kinetics & Toxicology- Man- (-1987); 560172 - Radiation Effects- Nuclide Kinetics & Toxicology- Animals- (-1987); 550601 - Medicine- Unsealed Radionuclides in Diagnostics; 560122 - Radiation Effects on Cells- Internal Source- (-1987)

Citation Formats

Steinstraesser, A., Kemmer, W., and Muth, H. Microdistribution of Thorotrast conglomerates in lymph nodes and radiation exposure of single lymphocytes. United States: N. p., 1979. Web. doi:10.1016/0013-9351(79)90133-6.
Steinstraesser, A., Kemmer, W., & Muth, H. Microdistribution of Thorotrast conglomerates in lymph nodes and radiation exposure of single lymphocytes. United States. doi:10.1016/0013-9351(79)90133-6.
Steinstraesser, A., Kemmer, W., and Muth, H. Thu . "Microdistribution of Thorotrast conglomerates in lymph nodes and radiation exposure of single lymphocytes". United States. doi:10.1016/0013-9351(79)90133-6.
@article{osti_5511352,
title = {Microdistribution of Thorotrast conglomerates in lymph nodes and radiation exposure of single lymphocytes},
author = {Steinstraesser, A. and Kemmer, W. and Muth, H.},
abstractNote = {In Thorotrast patients, chromosome aberrations of lymphocytes from peripheral blood are to be used as a biological dosimeter. To get a significant dose-effect relationship it is necessary to estimate the absorbed dose of a single lymphocyte during its exposure time. In individual cases only average values can be calculated, based on assumptions of special distributions of Thorotrast. At first effects of the size of Thorotrast conglomerates and of their space distribution on the ..cap alpha..-radiation dose distribution in their surroundings are described in a model. Then this model is transferred to the real dimensions and the histological structures of lymph nodes bearing Thorotrast. In some individual cases the microdistribution of Thorotrast has been determined in lymph nodes. Some of these results are demonstrated. According to these Thorotrast distributions, calculation of real absorbed dose of lymphocytes are performed. These values can be used for setting up a dose-effect relationship for biological dosimetry.},
doi = {10.1016/0013-9351(79)90133-6},
journal = {Environ. Res.; (United States)},
number = ,
volume = 18:1,
place = {United States},
year = {1979},
month = {2}
}